The Expression And The Clinical Significance Of Detecting Somatostatin Receptor 1 In Cervical Cancer

Cervical cancer is harmful to women's health,one of the primary malignant tumors.In recent years,the incidence of cervical cancer is on the top of Gynecologic Oncology in China.Every year about 1.3 million people catch the disease,the incidence of which is 1/3 in the same kind of diseases in the world. The occurrence and development of cervical cancer is a complex pathological process,with the exception of human papilloma virus(HPV) infection,the host oncogene activation and inactivation of tumor suppressor genes,some cytokines, growth factors and their receptors are also involved in the formation and development of cervical cancer.Integrated a number of reports,its etiology and pathogenesis of the present study has the following theory:1.HPV infection 2.telomerase 3.inhibitor of apoptosis protein and pro-apoptotic protein 4.tumor suppressor genes 5.growth factor and its receptor 6.enzyme,but the exact pathogenesis has not been understood yet.Somatostatin(SST) is a natural 14 peptide,found in the hypothalamus firstly, inhibits the secretion of pituitary growth hormone.With such a peptide expressed in a variety of organizations,people have found that its participation in a variety of biological effects,including inhibiting hormone secretion,regulation of nerve conduction,regulation of cell proliferation,and so on.Synthetic somatostatin analogues(SSTA) have longer plasma half-life,more powerful role than natural somatostatin.In recent years,somatostatin and its analogues on the inhibition of tumor cells have been growingly concerned about,a large number of studies have shown that somatostatin analogues can inhibit not only the vast majority of tumors with neuroendocrine features of proliferation,but also the common solid tumor growth.SSTR is a complete glycoprotein in structure.People and mice have five kinds of different SSTR subtypes,namely SSTR1 - SSTRS.One or more somatostatin receptors may exist on the vast majority of tumor cell surfaces which can be inhibited by SSTA.At present,the studies of somatostatin and its receptor in gynecologic tumors are as follows:SSTR in ovarian cancer has a higher expression rate,which provides a molecular basis in applying SSTA to ovarian cancer diagnosis and treatment.According to different literatures,the distribution of SSTR subtypes has differences,which may be related to testing methods and samples that are from different sources.The expression of SSTR in ovarian carcinoma has been studied and reported deeply,however,the literature on the expression of SSTR in other gynecologic tumors,such as cervical and endometrial carcinoma is much less.This experiment aims to study the distribution and expression of SSTR1 in cervical carcinoma,to approach the relationship between S STR1 expression and c linicopathological characteristics of cervical cancer and its clinical significance,in order to provide new ideas and methods for clinical diagnosis and treatment of cervical cancer.This experiment use immunohistochemistry method to study the expression of SSTR1 in 15 cases of normal cervical tissue,18 cases of adjacent cancer tissues,33 cases of cervical cancer tissues.All study patients were pathologically confirmed by surgery,and they did not receive any treatment before this study, including radiotherapy,chemotherapy or hormone therapy.The experimental datas use statistical software SPSS13.0 the simple statistical analysis,statistical analysis uses t tests,multiple sets of samples are compared using one-way ANOVA.When the p value is less than 0.05,we consider that it has statistically significant.The experimental results showed that:SSTR1 protein in tissues of each group have different levels of expression,and expression was mainly located in the serosa cells,in interstitial cells in each group did not express the basic. SSTR1 protein in normal cervical tissue,tissues,cervical cancer tissue was gradually increased intensity.SSTR1 protein expression in cervical cancer group was significantly higher than the next group of cancer and normal cervical group, there was a significant difference(P = 0.0049);next group in the expression of cancer is higher than the normal cervix group,but did not reach statistical level, the difference was not significant(P＞0.05).Cervical carcinoma SSTR1 expression in lymph node metastasis group and the group without lymph node metastasis,the difference was significant(P＜0.05);in PhaseⅠandⅡcervical cancer group phase of cervical cancer group compared the expression of intensity, the difference There was a significant(P＜0.05);in squamous cell carcinoma group and the expression of group,the difference was significant(P＜0.05); SSTR1 expression in terms of age,grade and depth of myometrial invasion group showed no significant differences(P＞0.05).In 33 cases of cervical cancer tissues, SSTR1 expression and TNM stage,histopathological type and lymph node metastasis(P＜0.05),with age,tumor differentiation,depth of myometrial invasion had nothing to do(P＞0.05).Concluded that the fully-mechanized:SSTR1 protein in cervical cancer tissue adjacent to cancer group was significantly higher than that of normal cervical group.High expression of SSTR1 may be related to the occurrence and development of cervical cancer and is closely related to malignant transformation. SSTR1 expression and TNM stage,histopathological type and lymph node metastasis(P＜0.05),with age,tumor differentiation,depth of myometrial invasion had nothing to do(P＞0.05).SSTR1 protein that,through various channels and mechanisms involved in the occurrence and development of cervical cancer.SSTR in cancer there is a high density of expression,which SSTA for gynecological cancer diagnosis and treatment provides a theoretical basis for specific and efficient SSTA,and radioactive derivatives SSTA for further development and application of,for cervical cancer diagnosis and treatment to provide a new target.However,more than 20 years of literature for the clinical treatment really are not many reports,and the results are unsatisfactory,there may be a key issue in vivo effects have not been solved. With in-depth study,carried out large-scale clinical trials as well as the more effective the successful development of somatostatin analogues,somatostatin analogues for diagnosis and treatment of cervical cancer a new way to open up.