The Preparation And Effects Study Of Targeting Drugs For Breast Cancer

For the tumor clinical treatment, we advanced a new drug delivery method to breast cancer cells with the nanoparticle produced by targeted HLA-G Ab and liposomes. We focus on two aspects as follow: First, targeting anti-breast cancer drug synthesis; Second, the initial detection of synthetic products. We summarized some data and analyzed some problems for this project.In this paper, the HLA-G antibody is as the target-oriented drug agents to achieve targeted delivery of drugs and drug-rich areas to the lesions, which could combine to HLA-G antigen on the surface of breast cancer cell, thus to reduce the side effects of drugs to improve drug utilization. Liposomes is selected as a drug nano-carrier, because of the advantages of liposomes, such as reducing drug doses toxicity, allergy and immune response, releasing slowly drugs, changing the distribution of drugs in vivo and targetting releasing drugs.To link the antibody to liposomes that carry drugs, SPDP is used as a linked bridge. The amino groups of antibody and the amino groups of liposomes are linked together by disulfide bond.As a result, in the process of drug synthesis, the efficiency of synthesizing PE-PDP is more than 80%; the sizes of taxol liposomes is in the nanometer level, in line with the idea before the experiment; entrapment rate of taxol liposomes is 55%. The valence of synthetic products is 50% as much as 50% valence of the antibody.