Retrospective Analysis Of Distribution Of Pathogens Of 2957 Children With Diarrhea

Objective:To monitor the distribution,and resistance of enteric pathogen of children hospitalized in our hospital in the last ten years and to offer the data for guiding reasonabe application of antibiotics and clinical treatment of diarrhea.Methods:Retrospective analysis of the cause and resistance of enteric pathogen of 2957 children hospitalized in our hospital from January 1999 to December 2008.Results:1.Pathogenic distribution:There were 2819 infective diarrhea pati- ents,in which there were 499 patients who were infected with the bacteria, accounted for 17.70 percent of the total number of patients,2256 with virus, accounted for 80.08 percent,and 45 with both bacteria and virus,accounted for 1.63 percent,while 18 with fungi,accounted for 0.64 percent.Among all the patients,425 had identified pathogen,in which 379 were rotavirus,accounted for 89.19 percent and bacteria and fungi accounted for 6.59% and 4.23%, separately.2.Age distribution: Most of the children with infective diarrhea were infant and young children,most of which were infected with virus (rotavirus is capital).Then,chidren above the age of 3 were infected with bacterial mostly. 3.Distribution of time and season:The rates of pathogenic bacteria changed in the recent ten years: 2001 was lower than 2000 (p<0.05),and the average of 2003 and 2004 was higher than 2000 and 2001(p<0.05),while the average of the year between 2006 and 2008 was lower than the year between 2003 and 2005 (p< 0.05).Simultaneously,the rates were different among seasons:summer and autumn were obviously higher than spring and winter (p<0.01),and spring was higher than autumn,but summer and autumn had little difference.Then,the peak time of rotavirus infection was autumn and winter,and these two seasons had little difference,at the same time ,there was no obvious difference between spring and summer.4.Endemic distribution:The urban field and jurisdiction of Changchun had no difference in infection with bacteria and rotavirus.There was little difference between Changchun area and other area in infection with bacteria,but the rate of rotavirus infection in Changchun area was lower than other area.There was some difference among the jurisdictions of Changchun in infection with bacterium:the city of Jiutai was lower than the other three cities (Nongan, Yushu, Dehui),and other three cities had little difference. However,the four cities had no significant difference in infection with rotavirus.5.Construction and resistance of pathogenic bacteria:Shigella,saimonella and opportunistic pathogen were the main pathogenic bacteria of intestinal tract in Changchun area.The rate of resistance to cefuroxime of these bacteria was highest,and SMZ-TMP was higher. These bacteria were sensitive to fluoroquinolones and third-generation cephalo- sporins,while the rates of sensition to imipenem and meropenem were highest. However,the rates of sensition to antimicrobial agents were different between these bacteria.Conclusion:1.There were many species of enteric pathogenic bacteria causing children infective diarrhea.Bacteria and virus were the main causes.Shigella and saimonella were the main pathogenic bacteria of intestinal tract and rotavirus was the most common virus.2.Most of the children with infective diarrhea were infant and young children,so we must take care of them and protect them from these causes.3.The rate of bacterial infection is changing.The species and resistance of pathogenic bacteria are different amoung different areas and times.Therefore,we must detect them endlessly and think seriously of detection and adoption of antibiotics.