Investigation On The Release Model And Mechanism Of Chinese Medicine Effective Position In HPMC Matrix Tablets

Hydroxypropyl methycellulose (HPMC) is one of the most widely used sustained-release matrix material,applied to a large number of Sustained currently Preparations of modern research, the drug research of HPMC matrix tablets is relatively mature. Relatively speaking, the research of the Chinese medicine effective position in HPMC matrix tablets is backward, and the release behaviors include the system research on mathematical release model and the releasing mechanism are very little in current. So, preliminary Study to the release behaviors is of great realistic significance.Taking Astragloside as model of soluble drug, the total puerariae flavones as model of insoluble drug, investigate the the release acts of the effective part with different nature in the hydrophilic matrix gel of HPMC. Research the relation of drug release with the time and the dissolution of HPMC, by calculating the prescription component equivalent molecular weight (Meq), derived quantitative mathematical Model. Further explore and study the release behaviors of Chinese medicine effective position and the factors which effect drug release; investigate the release model of the Chinese medicines effective site in hydroxypropyl methycellulose matrix tablets, is used to predict drug release. The mathematical model by matrix erosion rate and drug release from HPMC K15M were established for the fractional Astragloside released asThe release equation of total puerariae flavones isIn comparison with the data of HPMC K4M matrix erosion and Astragloside release from HPMC K4M matrices, theoretical value agreed well with experimental data. The equation can predict the release of similar tablets. Conclusion: The mathematical model can be satisfactorily applied to Chinese medicines effective position release, which is governed by matrix erosion.