The Effect Of Salbutamol Aerosol On Sevoflurane Induction In Elderly Patients

PurposeTo study the effect of salbutamol aerosol on sevoflurane induction in elderly patients.MehtodsAfter obtaining Ethics Committee approval,30 patients,aged 65-75-yr-old,ASA gradeâ… -â…¡undergoing elective surery with general anaesthesia randomly entered the study.The Patents allocated randomly by closed envelope technique to one of two groups and each group was 15 patents.One group was given the salbutamol aerosol 30 minutes before the induction and the other was black.The patients were induced by 8L/min fresh flow O₂ and 6%sevoflurane with patient controlled inhalation induction.During the induction,we recorded the data:heart rate(HR),invasive blood pressure(IBP),pulse oxygen saturation(SPO₂),inspiratory sevoflurane concentration(InSEV%),end-tidal sevoflurane concentration(EtSEV%), bispectral index(BIS),loss of consciousness(LOC),apnoea(＞20s),movements, laryngospasm and coughing.Meanwhile,we draw the arterial blood samples to analysis the concentration of sevoflurane in arterial blood.ResultsWhen the induction begin,EtSEV%grown up step by step,InSEV%first dropped and then keep stability,BIS dropped step by step,HR,MAP first keep stability and grown up in the middle and at last significantly dropped.LOC in the experimental group was 76±12 s and in the placebo group was 75±13 s,P＞0.05.The concentration of sevoflurane in arterial blood and EtSEV%at 130 s in the experimental group were 63.2±18.7 ppm,3.45±0.89,in the placebo group were 54.0±16.8 ppm,3.60±0.33,P＞0.05.The concentration of sevoflurane in arterial blood and EtSEV%at 250 s in the experimental group were 75.4±16.1 ppm,4.14±0.36,in the placebo group were 74.0±26.9 ppm,4.06±0.31,P＞0.05.The end at 330 s,EtSEV% and BIS in the experimental group were 4.33±0.31,35±8,in the placebo group were 4.25±0.31,36±7,P＞0.05.The BIS at 240s was significantly different between the two groups,the experimental group was 38±9,the placebo group was 48±14,P＜0.05.ConclusionsSalbutamol aerosol has no effect on sevoflurane induction in elderly patients.