Clinical Significance Of MCM2 And Ki-67 In Non-Small Cell Lung Cancer

Purpose:By detecting the expression of MCM2 and Ki-67 in the resected tissue of non-small cell lung cancer and benign lesion to evaluate their clinical significance in the carcinogesis and diagnosis of non-small cell lung cancer.Methods:Immunohistochemical staining was used to detect the expression of MCM2 and Ki-67 in 72 resected non-small cell lung cancer and 18 benign lung lesion,and to analys their correlation with the clinical features.Results:The expression of MCM2 and Ki-67 were positive in the Cell nuclei of tuomor cells with the light microscopy.The expression of MCM2 was positive in all of the 72 resected NSCLC and that was negative in the 18 benign lung lesion.The expression of MCM2 was correlated with histology of NSCLC,the expression of MCM2 in squamous carcinomas was higher than that in large cell carcinoma and adenocarcinoma(P＜0.01);the expression of MCM2 was correlated with differentiation grade of NSCLC, the poorer differentiation,the higher expression(P＜0.05).The expression of Ki - 67 was correlated with differentiation grade of NSCLC,the poorer differentiation,the higher expression(P＜0.05).The expression of MCM2 was higher than that of Ki-67,and was correlated with high Ki - 67 labeling index.Conclusions:As a specific cell proliferation marker,the expression of MCM2 was significantly correlated with the clinical features of NSCLC,and was correlated with high Ki - 67 labeling index.The expression of MCM2 and Ki-67 in the tissue may be used as potential clinical tool for the diagnosis and prognosis of non-small cell lung cancer.