| Since penicillin published 50 years,because of a great deal of emergence of the antibiotics,once make the germs infection disease that mankind feel helpless get the valid control,several hundred kinds of anti-bacterium medicine almost can repress and kill to put out all with the result that germ.At the same time,synthesize the anti-bacterium medicine to abuse because of the antibiotics and chemistry,cause to bear the medicine germ stub play to increase,the germs bear the medicine and widespread creation and bear the medicine infection to have already become a big hard nut to crack of the field of doctor,but lack the hard nut to crack that valid means by the root solve again at that time.The Chinese medicine quickly rise,will open to split to infect with the new era that sex disease make a diagnosis and give treatment,it not only can make the germs infection disease get the valid control,but also may promote the Chinese medicine and medicine source develop,expanding the usage realm of the Chinese herbal medicine,the exaltation that insures to behave a healthy level provides the new guarantee.The Angelica acutiloba kitag belongs to the erect herbaceous plant of Umbelliferae, the modern pharmacology learns the pain that the research enunciation Chinese herbal medicine Angelica acutiloba kitag essential oil anti-choline function lowers the blood pressure town,eliminating inflammation the function.The recent years research also discovers,the Angelica acutiloba kitag medicine material water withdraws the thing to have the liver of protect,smooth muscle of exciting womb,promote the immunization,poisonous function of cell and activate the egg white to arouse the activating enzyme to live to wait the function.The medicine chemistry research express that the Angelica acutiloba kitag mainly implies the essential oil, phospholipin,Coumarins,sterine,glycose and polycose.But to a cent of the Angelica acutiloba kitag essential oil outside of a cent of chemistry and anti-bacterium pharmacology function did not appear in newspaper the way,for the sake of the chemistry composition and the pharmacology functions of further thorough research Angelica acutiloba kitag,bing the formal medicine material for the Angelica acutiloba kitag,bring into the national medical dictionary to provide science from now on according to,this experiment carries on to compare to the chemistry composition and anti-bacterium pharmacology functions of the east Chinese angelica to study systematically.Does this experiment apply the SFE-CO2 and the GC-MS method to analysis of the extracts.The medicine material extract behind continues to withdraw with 80% ethanol.The 80%ethanol withdraws the part to use the hexane,EtOAc and BuOH extract.Further separate and make sure to gain the structure of the compounds. Extract the thing to carry on the anti-bacterium experiment to the different melting agent.Experiments:(一)10components were identified which included Bicyclo(6,3,0)undeca-dien-3-one,5,5-dimethyl and ect of the essential oil from Angelica acutiloba kitag were analysed for the first time.The SFE-CO2 extracted the volatile oil chemistry composition in the Angelica acutiloba kitag that withdraws with traditional method to have already shown the markedly difference.(二) Bying the silica gel colum separately,getted nine crystal compounds totally.Basising physics and chemistry property and spectrum datas of the 1H-NMR,13C-NMR,MS,IR,DEPT,1H-1HCOSY,HMQC.Make sure once compounds:Tridecyl tridecanoate(1), Tetratriacontyl alcohol(2),Docosanol(3),Gaidic acid(4),Tricos-9-enoic acid (5),Stigmasterol-5,22-dien-3-ol(6),β-daucosterol(7),Diosmin(8),Gallic acid-6-O-β-D-glucopyranoside(9).(三) Among them compounds(1),(2),(5),(6),(8),(9) the first time are from the Angelica acutiloba kitag.(四) The dissimilarity extracts the thing anti-bacterium medicine dint experiment result enunciation,The positive BuOH of the Angelica acutiloba kitag extract the thing contain the most strong obviously anti-bacterium function. |
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