Sevoflurane Anesthesia Patients Induced Controlled Hypotension In The Safety And Feasibility As Well As Their Cerebral Oxygen Supply And Demand Balance And The Metabolism Of The Brain

Purpose:To discuss sevoflurane anesthesia patients induced controlled hypotension in the safety and feasibility,as well as their cerebral oxygen supply and demand balance and the metabolism of the brain.Methods:Thirty six patients scheduled for elective surgery were randomly divided into three groups:Group A,sevoflurane-maintained normal arterial tension.Group B, sevoflurane and SNP-induced hypotension.Group C,isoflurane and SNP-induced hypotension.Group A and B inhalation 3～6%of the sevoflurane;group C 1.5～3% of the isoflurane.Group B and C target control infusion of SNP(0.5～5μg/kg.min), adjust SNP infusion rate for controlled hypotension.Record BP,HR,ECG and BIS etc, and arterial blood samples and jugular blood samples were taken snchronously for measuring blood gas and blood lactate,SOD and MDA levles.Record the time of revival.Results:In group B and C,the blood pressure descend fast and stable,there were significant changes in blood glucose after controlled hypotension in group C.During controlled hypotension HR,ECG,BIS,D(a-jv)O₂,LD,SOD and MDA showed no significant change.The time of revival of Group A and Group B was shorter than Group C.Conclusion:Application of sevoflurane anesthesia had no effect on the patient of controlled hypotension brain tissue perfusion and brain metabolism.The patients of controlled hypotension with sevoflurane anesthesia was safe and feasible,and the quality of postoperative recovery was better.