Effects Of Huang Li Schisandra Paste On Mice On Carbon Tetrachloride Caused Acute Liver Injury

OBJECTIVE:To observe the protective effects of Huang Li Schisandra paste on mice with acute liver injury.And to study its function and mechanismMETHODS:Use of carbon tetrachloride(CCl₄) induced acute liver damage model to study,â‘ The experimental animals were randomly divided into six groups according to the body weight:Normal control group,CCl₄ model group,Huang Li Schisandra paste large,medium and small dose group,the positive control group (silybin).In serum alanine aminotransferase(ALT),aspartate aminotransferase (AST) and glutathione(GSH),glutathioneperoxidase(GSH-PX) in the liver and absorption Pulp malondialdehyde(MDA),superoxide dismutase(SOD).and the changesâ‘¡Model preparation.Every day fills the stomach one time,5 days,start from the 4th day to fast continuously to be unable to restrain water 24h,the 5th day gives medicine latter 1 h.Besides the normal control group,other even abdominal cavities inject 0.1%CCl₄0.2 ml/20g.â‘¢Specimen gathering,the mouse is filled stomach after CCl₄ 24 h,after the complete eyeball draws blood,escapes the cervical vertebra execution,cuts open the belly,takes out the liver,separately weighing takes out 0.1 g, joins 0.9 mL physiological saline to carry on the refining.RESULTS:Huang Li Schisandra paste decreased significantly due to lead poisoning CCl₄ mouse serum alanine amino-transferase(ALT),aspartate aminotransferase(AST),Reduced MDA levels in liver tissue,liver tissue SOD enhance its role in the positive drug group with similar.Increase glutathione(GSH), glutathione peroxidase(GSH-PX) and the content of the model group,Compared with the model group were significantly different.CONCLUSION:Huang Li Schisandra paste on CCl₄ caused by acute and chronic liver injury is a protective effect.The mechanism may be removed and oxygen free radicals,inhibiting lipid peroxidation,Enhance the body's antioxidant capacity.It compares the function with silybin group to be similar,...