The Study Of Causes And Trerapy Of 393 Cases Of Infection Associated Neutropenia-393 Cases Report

Objective: To investigate the etiology, clinical features, treatment and healing effects of neutropenia, analysis the relevance between neutropenia and virus infection, provide clinical foundation for diagnosis and treatment of neutropenia.Methods: Analysis 393 cases of neutropenia, summarize the main clinical manifestations, virology examinations, treatment as well as healing effects and explore the relevance between neutropenia and virus infection.Results: (1) 393 cases of this group, neutropenia occupied 308, neutrophil deficiency occupied 85; male to female ratio 1.5:1; the percent of patients younger than 3-year-old were 66.2%, with other age groups significantly different; ratio of urban to rural areas ratio 1.73:1; it occurrenced throughout the year,percent of summer was 41.2%, the other season groups were significantly different. (2) The percents of neutropenia within the course of one week ,two weeks,more than two weeks were separately 65.9%,22.4%, 11.7%,between the courses there were significant difference(P=0.02). The percent of neutropenia recovered within 1-5 days was 81.8% (54/66), The percent of neutrophil deficiency recovered within 1-5 days was 52.1% (12/23). (3) The percent of fever as the first manifestation were 64.4% (253/393), high fever 47.4%. (4) 393 cases did the virology examinations, positive rate was 88.3%, percent of single-species virus infection is 67.1%, percent of two kinds or more virus infection is 32.9%. (5) Exam ROV, MeV, HSV, RUV, MmV, CBV, CP, RSV, EBV, ADV, CMV, MP, HPV antibodies as convention, CBV-IgM positive rate was 29.3%. (6) The percent combined anemia was 38.7%; combined thrombocytopenia were 25 cases. (7) Neutropenia developed with bacterial or fungal infection got a percengtage of 60.3% (76/126). (8) 33 cases took bone marrow examination, 87.9 % of which prompted irritational bone marrow, two cases prompted ITP performance, one case prompted Hereditary Oval Erythrocytosis. (9) The percent of useing antibiotics for treatment was 95.2%; 7cases used CSF. 183 cases(46.6%) used Diyu Shengbaipian, what made significant difference with the lowest netrocyto(P = 0.012).Conclusion: (1) Neutropenia was more in cities and in summer,≤3-year-old was the high incidence age.(2) Virus infection was the common factor leading to neutropenia, CBV occupied about 1/3. (3) Neutropenia was only assocciatet with the virus infection. (4) The clinical performance was related with primary diseases, but in more than half cases the first performance was high fever. (5)Most neutropenia was a benign process. (6) Diyu Shengbaipian could be used for therapy. (7) Neutropenia could combine anemia and thrombopenia, neutropenia with another two-system lower than normal without improvement more than a week should routinely take bone marrow exam to except other blood system diseases and HLH.