Changes Of Ambulatory Blood Pressure And Blood Pressure Variability In Senile Diabetics Type 2 Accompanied With Primary Hypertension

Objective. To observe the changes of ambulatory blood pressure and blood pressure variability in senile diabetics type 2 accompanied with primary hypertension.Methods: Select 160 old-age patients and divide them into two groups according towhether they have diabetes or not: Group A is one of diabetes and essential hypertension(82 persons), of whom males are 70 and females are 12, aged between 60 to 85((73.3±12.3). Group B is one of essential hypertension of 78 persons, of whom males are 62 and females are 16, aged between 61 to 86(73.8±12.1). Diagnostic standard answers for (1) diagnostic standard of Type II diabetes modified and put forth by American Diabetes Association in 1997; (2)new standard for hypertension classification of essential hypertension. On the basis of history of illness, physical examination and laboratory check, all cases exclude symptomatic hypertension, secondary hypertension, abnormal liver function and renal insufficiency. 24-hour ambulatory blood pressure monitoring and blood pressure variability monitoring are done.Results: The night systolic pressure of senile diabetics type 2 accompanied with primary hypertension rose remarkably, the daytime systolic blood pressure standard deviation and its coefficient of variance of senile diabetics type 2 accompanied with primary hypertension increase remarkably, p<0.05, the difference of blood pressure between day and night and the rhythm change showed remarkably difference in comparison with those of senile patients suffering from hypertension alone.Conclusion: The nocturnal blood pressure of the patients suffering from senile diabetics type 2 accompanied with primary hypertension are kept at higher level as and increase blood pressure variability compared with those of the patients with hypertension alone, indicating that the function of diurnal and nocturnal blood pressure regulation is obviously damaged. Therefore, improvement of insulin sensitivity might restore cardiovascular hemodynamics,thus reducing the possibility of cardiovascular complications.