| Hepatocellular carcinoma is a common malignant tumor with higher invasion and metastastic potential,which lead to a poor prognosis of major patients and a high recurrence post operation.Proliferation and migration of cancer cell are the key steps for hepatocellular invasion and metastasis.HLJ1 is a new member of DnaJ-like heat shock protein 40 family.Previous studies have revealed that HLJ1 could regulate cell proliferation and migration.HLJ1 can inhibit cell devision and proliferation by up-regulating P21WAF1and down-regulating Cyclin D in a P53-independent manner.Furthermore,HLJ1 can inhibit cell migration by up-regulating cadherin E.In this research,we detected the expression levels of HLJ1 in the tissue of HCC for the first time,and analyzed the relationship between the HLJ1 expression levels and the clinicopathological characteristics of HCC.Objective:To analyze the expression of HLJ1 in the tissues of hepatocellular carcinoma(HCC)and the correlation between its expression and clinical pathological characteristic.Methods:HLJ1 mRNA expression level was determined in 32 HCC tissues and their paracarcinomatous liver tissues(PCLT)by reverse transcription polymerase chain reaction(RT-PCR).The correlation of HLJ1 expression level with clinicopathologic variables was also analyzed.Results:HLJ1 mRNA expression level was significantly lower in HCC than in PCLT(1.18±0.82 vs 1.92±1.15,P＜0.05).Importantly, the HLJ1 mRNA expression level correlated with the Edmondson-Steiner grade(P=0.010)and vein invasion(P=0.001).Conclusion:Our study indicates that HLJ1 mRNA expression level in HCC tissues is significantly lower than that in PCLT.HLJ1 may participate in the cell proliferation and migration of HCC cell.
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