CT-based Liver Volumetry In A Porcine Mode And Its Value In Living Donated Liver Transplantation

Purpose: To investigate the correlation between preoperatively calculated and postoperatively measured porcine livers volumes and weight by multislice CT and its clinical value in living donated liver transplantation (LDLT). Purpose of the study was to assess the influence of the perfusion state on liver volume and the validity of the preoperative liver volumetry prior to LDLT.Methods: In the experimental study, 10 porcine were enrolled to undergo mulitslice CT scanning at enhancement phases. The liver volumes in the different perfusion states were calculated based on post-processing workstation. The livers were weighted and their volumes were determined by water displacement prior and after fluid infusion to achieve a pressure physiologically found in the liver veins. statistical analysis was used to test the relationship between the CT-measured liver volume and the volume measured by water displacement and the weight of the livers, and the relationship was expressed by scatter graph and linear equation. Use the clinical information we have already got to validate the linear equation.Results:1. The mean of liver volumes calculated by CT before operation was (244. 6±39)ml , the mean weight of postoperative livers measured during operation was (199. 3±22. 5)g, which were positively correlated, and could be expressed in the equation Wact (g)=0. 467×V(ct)+85g。2. the mean volumes of postoperative livers measured was(184.2±24.5)ml, which were positively correlated, and could be expressed in the equation Vact=0.519×Vct+57.1ml. 3.Use t two-tail test to compare the volume measured in the surgery with the data that translated with the equation, P>0. 05, there was no specific difference between them.Conclusion: There was a significant positive association between the volume measured by CT and the postoperative volume and weight of liver. Before the operation, we can use the equation to calculate the volume and weight of the target liver more accurately, and to correct the warp of the volume measured by CT. This provides a great base for us to evaluate the volume of liver before the operation. Using multislice-CT to measure the volume of the target liver in the same condition showed an excellent accuracy.