Increased Levels Of PAPP-A And IGF-Ⅰ In Peritoneal Fluid Of Patients With Endometriosis

Objective: To detect the concentration of PAPP-A and IGF-I in the peritoneal fluids (PF)of women with endometriosis,so as to investigate the role of PAPP-A and IGF-I in the pathogenesis of endometriosis.Methods: Enzyme-linked Immunosorbent assay (ELISA) was used to detected the concentration of PAPP-A and IGF-I in the peritoneal fluid of 39 patients with different stage of endometriosis and 25 patients without endometriosis.Results: The mean levels of PAPP-A and IGF-I were higher in peritoneal fluid from patients with endometriosis than controls(P<0.05).According to the staging criteria of r-AFS,the level of peritoneal PAPP-A in the patients with stage III-IV endometriosis were significantly higher than those in the patients with stage I-II endometriosis. Significant correlation was found between the stages of endometriosis and the levels of PAPP-A in these patients(r = 0.523,P<0.05). There was no significant correlation between the levels of PAPP-A and dysmenorrheal score(P>0.05). We found no significant correlation bewteen the PF levels of PAPP-A and IGF-I.Conclusion: PAPP-A and IGF-I may play an important role in the pathogenesis of endometriosis . There was significant correlation between the PF levels of PAPP-A and the stages of endometriosis. There was no significant correlation between the PF levels of PAPP-A and IGF-I.