A Case-Control Study On The Risk Factors Of Colonic Cancer

Objective: To explore the major risk factors of colonic cancer and provide a scientific basis for strategies of colonic cancer prevention.Methods: A hospital-based 1:1 matched case-control study was adopted. 219 cases of colonic cancer that pathological diagnoised during May 1^th,2006 and Sep 1^th,2007 at the first, the second and the third affilfated hospital of XiangYa college were enrolled. Patients without colonic cancer or other cancer, however have the same gender, the same age (differ within 3 years) and receiving treatment at the same hospital as cases were selected as controls. Face-to-face interviews were carried out and the investigation involved the life style ,dietary habits, history of diseases and family history of cancer. Matched Chi-square test and conditioned logistic regression model were used for univariate andmultivariate analysis to estimate odds ratios (?) and the 95% confidence interval (95%C1).Results: Univariate analysis showed that colonic cancer was associated with low education level (χ²=8.791 ,P=0.003 ), peasantry (χ²=4.914,P=0.027), low-income levels (χ²=8.594,P=0.003), lack of exercise (χ²=11.571,P=0.001), sedentary lifestyle (χ²=10.983,P=0.001),constipation (χ²=7.321,P=0.007), low vegetable intake (8-13times /week:χ²=4.648,P<0.043;≤7 times/week:χ²=28.372,P=0.000), high meat intake (χ²=4.366,P=0.037), high-salty foods intakes (χ²=6.195, P=0.013), animal fats used cooking oil (χ²=15.284,P=0.000), high animal bowels intake (χ²=20.645,P=0.000), history of gastric and intestinal ulcer (χ²=4.654,P<0.05), history of cystic disease (χ²=5.565, P=0.018), history of appendicitis (χ²=13.885,P<0.01), cancer history in the first degree relatives (χ²=13.829,P<0.01) . Meanwhile, colonic cancer was not associated with smoking (χ²=1.221, P=0.267), drinking (χ²=0.860,P=0.354), areca (χ²=2.064,P>0.10) and pickle (χ²=3.571, P=0.059) . Multivariate logistic regression analysis showed that high meat intake((?)=2.854,95%CI: 1.269-6.419), high animal bowels intake ((?)=2.869, 95%CI: 1.364-6.034), low vegetable intake ((?)=4.663, 95%CI:2.049-10.661), lack of exercise ((?) =4.480, 95 %CI:1.602-12.524), sedentary lifestyle((?) =6.110, 95%CI: 2.774 -13.457), animal fats used cooking oil ((?)=6.378, 95%CI: 2.716- 14.981), history of appendicitis ((?)=8.338, 95%CI:1.237-56.215), cancer history of first degree relatives ((?)=15.833, 95%C7: 2.653-95.090) were the risk factors of colonic cancer.Conclusion: Colonic cancer could be affected by multi-factors, including low vegetable intake, high meat and animal bowels intake, lack of exercise, sedentary lifestyle, animal fats used cooking oil, history of appendicitis and cancer history in the first degree relatives. Meanwhile, colonic cancer was not associated with smoking, drinking, areca and pickle.