| Objective FSH and LH may play an important role in regulating bone mass in peri-and post-menopausal women. The aim was to investigate the relationship between age-related concentrations of serum FSH and LH with bone mineral density (BMD), prevalence of osteoporosis in native Chinese women.Design and subjects Cross-sectional study of 699 healthy Chinese women aged 20-82 years (mean [SD],45.2 [14.6]years).Measurements Serum FSH and LH concentrations were measured using RAI, and BMD were measured using DXA at the postero-anterior (PA) spine, lateral spine, total hip and distal forearm. Evaluate the relationship between serum FSH and LH concentrations with age, BMD, prevalence and risk of osteoporosis.Results TThe cubic regression model best described the changes in serum FSH (R~2 = 0.543, P = 0.000) and LH (R~2 = 0.324, P = 0.000) concentrations with age. FSH and LH concentrations increased with age from 40 years, and decreased with age at 60 years. The geometric mean values (SD) of serum FSH and LH in premenopausal women is 3.94±2.08IU/l and 7.51±2.58IU/1, respectively, in postmenopausal women is 28.8±1.88IU/1 and 25.6±1.95IU/1, respectively. Serum FSH was significantly positively correlated with serum LH (r = 0.734, P = 0.000). FSH and LH were negatively correlated with BMD at different skeletal regions, correlation of FSH and BMD (r= 0.597-0.492) is always better than LH and BMD (r = -0.332- -0.452), and the negative correlation of FSH and LH with BMD at PA spine is best than that other skeletal sites. At the PA spine, lateral spine, total hip, and ultradistal forearm, the mean prevalence of osteoporosis of the quartile in FSH were 0.057%, 0.43%, 27.1% and 30.9%, respectively, in LH were 2.14%, 4.43%, 19.5% and 26.0%, respectively. Compared with 1st and 2nd quartile, the prevalence and risk of osteoporosis in 3rd and 4th women were significantly increased; compared with 3rd quartile, the prevalence and risk of osteoporosis in 4th quartile women were also increased, especcially at the PA spine.Conclusions These data suggest that the circulation concentrations of FSH and LH may play an important in the acceleration of bone loss in Chinese women. Future confirmatory longitudinal studies are needed. |
