Expression And Significance Of Peroxisome Proliferator-activated Receptor γ In Acute Pancreatitis.

Objective:To observe the changes of PPARγin rats with acute pancreatitis,and to explore relationship between PPARγwith acute pancreatitis.Methods:Adult Wistar rats were randomly divided into three groups.Eight rats of each groups were killed at 1,6,12h points after model was established and pancreatic tissue was collected.RT-PCR and immunohistochemistry were used to detect the lever of PPARγmRNA and protein in 54 pancreatic tissue of rats with acute pancreatitis.The relationship between the expression and the pathological changes was analyzed statistically.Results:At 1 6 12hour the leves of PPARγand PPARγmRNA has no significantly in C group(p＜0.05).at 12 hour the leves of PPARγand PPARγmRNA in C Group and Mgroup is higher than Cgroups(p＜0.05);at 12 hour the expressions of PPARγand PPARγmRNA in Cgroups is highest,Cgroups is lowest(p＜0.05).The expression of PPARγand PPARγmRNA is positive correlated with the scores of pancreatic tissue pathology(r=0.341 0.311).Conclusion:PPARγmay play an important role in the pathogenesis or progression of acute pancreatitis,and the level of PPARγmay be a prognostic indicator in actue pancreatitis.