The Relationship Between NF-κB Expression And Clinical Pathology In Chronic Kidney Disease

Objective To investigate the role of nuclear factor kappa B(NF-κB) in the pathogenesis of chronic kidney disease (CKD).Methods Two-step immunohistochemistry was used to detect NF-κB expression in renal tissue of CKD group and normal control group. At the same time, the relationship among NF-κB expression, inflammatory activity of renal tissue, proteinuria and hyperlipidemia were examined.Results NF-κB expression in CKD group and normal control group was [ (5. 62±1.42)% vs(1.82±0.38)%, in glomeruli] and [(43.93±9. 43)% vs (10.61±2. 26)%, in tubules],respectively(P<0.05). Compared with that of control group, NF-κB expression in CKD 1 group, CKD 2 group and CKD 3 group was significantly increased respectively(P<0.05). Compared with that of CKD 3 group, NF-κB expression in CKD 1 group and CKD 2 group was drastically increased respectively (P<0.05). But there was no difference of NF-κB expression between CKD 1 group and CKD 2 group (P>0.05). NF-κB expression in different pathological types was respectively higher than that of the control (P<0.05). NF-κB expression in MsPGN group was statistically different from that of MCN group (P<0.05). But there were no differences of NF-κB expression among FSGS group, MN group, IgA group and MPGN group. NF-κB expression in (≥10min) group was significantly higher than (<5mim)group and (5～10min)group respectively (P<0.05). NF-κB expression in glomeruli and renal tubules had positive correlation with inflammatory score of renal tissue respectively (r=0.64 and 0.71, P<0.05). Compared with that of (0.15～3.5)g/24h group, NF-κB expression in≥3.5g/24h group was significantly increased (P<0.05). NF-κB expression in glomeruli and renal tubules had positive correlation with 24-hour urinary protein excretion respectively (r=0.52 and 0.78, P<0.05). Compared with that of normal blood lipid group, NF-κB expression in hyperlipidemia group was significantly increased (P<0.05), while no statistical difference was observed in renal tubules(P> 0.05).Conclusion NF-κB may play an important role in the pathogenesis of CKD.