Quantitative Study On ~1HMRS To Temporal Lobe Epilepsy

Objects:To evaluate the quantitative diagnosis values of 1H-MRS to TLE.Methods:Thirty three cases of patients who were diagnosed to be TLE by clinic and EEG check and neurons-imaging(Head CT and MRI scanning) accepted 1HMRS analysis which were located in the inner temporal lobe and SVS-SE sequence were applied with TR1500ms, TE135ms,average 192,voxiel 10—20mm~3,acquisition time 4 minutes and 50 seconds, the integrates of the waves of NAA and CHO and CR on 1HMRS were analysis and the ratio of NAA/(CHO+CR) were calculated on the workstation.The frequency and attack type and the whole courses of TLE were asked,registered and scaled by the degree of their seriousness.T-test were used for our study to statistics the trends of every index and Spearman-r were used for the relations between clinic index and the ratio of NAA/(CHO+CR).Results:The integrate of NAA(mean=7.524) and the ratio NAA/(CHO+CR)(mean=0.421) decreased significance on the side with lesion of patients of TLE than on the healthy side (mean=8.154 and 0.866 respectively,P＜0.05),meanwhile CHO increased significance on the lesion side than the healthy side(mean=6.891 and 5.443 respectively,P＜0.05).No matter the lesion occurred on single side or bilateral,the ratio NAA/(CHO+CR) decreased the same,there was no significant difference between two group(P＞0.05).A significance negative relationship was observed between the ratio NAA/(CHO+CR) and the attack type(spearman r=-0.269, P＜0.05),and the frequency(spearman r=-0.572,P＜0.01),but no relationship between the ratio and the whole courses of TLE(spearman r=0.077 P＞0.05).Conclusion:The application value of 1HMRS to TLE is cleared in this study and the ability of 1HMRS to evaluate the clinic severity of TLE is made sure to be probable.