Clinical Significance Of ProGRP In Diagnosis And Treatment In SCLC

Objective: To discuss the biological characteristic of serum ProGRP and clinical significance of SCLC diagnosis, monitoring, effect evaluation and prognosis as well as correlation between ProGRP and NSE level. Seeking for tumor marker with high sensitivity and differentia, it will provide scientific basis for SCLC prevention and treatment.Methods: 1221 cases of lung cancer patients and 500 cases of healthy control group during October 2005--October 2007 period in Shanxi Cancer Hospital were collected, Serum ProGRP and NSE level between lung cancer patients before and after treatment as well as healthy subjects were detected with ELISA. Meanwhile,lung cancer patients were also performed related image examination. SPSS11.0 software package was applied to process statistically.Results: The serum ProGRP median value of 270 cases of SCLC patients before treatment was 544.48pg/ml,the Sensitivity was 84.07%, it was significantly higher than NSCLC group and healthy control group, the difference had significance statistically(P<0.001). when the clinical staging grade increased,cases which ProGRP level was higher than critical value also significantly increased, examined sensitivity increased, the difference had significance with group comparison of sensitivity (P<0.01). the treatment effect of 270 cases of SCLC patients were evaluated that ProGRP level of patients with complete alleviation were significantly lowered, ProGRP level of patients who symptom were unchanged or in advance were significantly higher than critical value, the difference had significance statistically (P<0.001 respectively). The serum ProGRP level was lower than critical value for the SCLC patients who lived to 3 months,6 months,12 months and 24months after treatment, the difference had no significance with comparison among four groups (P>0.05). The serum ProGRP level of patients who had relapse,metastasis or in advance within 24 months after treatment were significantly metastasis occured, ProGRP higher than healthy survivor after treatment, it was also higher than the serum ProGRP level before treatment, the difference had significance statistically (P<0.001 respectively). The research results also indicate that the change of ProGRP level had significant correlation with tumor size showed by image system,when tumor shrank and disappeared, ProGRP level was apparently lower than that before treatment; when diffusion and level was apparently higher than that before treatment. ProGRP and NSE level had significant correlation with SCLC detection, r =0.243, P<0.001. ProGRP and CEA had no correlation with SCLC detection, r=0.014 ,P =0.706。Conclusions: The detection of serum ProGRP can be used as sensitivity and differential index for SCLC diagnosis, condition monitoring,effect evaluation and prognosis, it can also furtherly improve the sensitivity combined with NSE detection.