Clinical Study On Integrated Backscatter Parameters In Assessment Of Hepatic And Renal Toxicity By Symphysicchemotheraphy (Paclitaxel And Cisplatin)

Objective:To evaluate the clinical value of integrated backscatter (IBS) parameters in detecting the hepatic and renal toxicity by symphysic chemotheraphy (Paclitaxel and Cisplatin).Methods:Forty-five patients have finished 4 cycles of TP symphysic chemotherapy (Paclitaxel and Cisplatin) (21days per cycle) or more for malignancy treatment (A group) . Until the finally day of TP symphysic chemotherapy , the shortest course of treatment is four cyclese and the longest course of treatment is seven cyclese ;the total minimal dos of PTX is 480mg/m2 and the total maximal dos of PTX is 840 mg/m2;the total minimal dos of DDP is 400mg/m2, the total maximal dos of DDP is 700mg/m2. And forty volunteers without liver and kidney diseases served as the control group (B group) were included in our study. The conventional ultrasonic parameters of liver and ren were respectively measured. And the conventional ultrasonic parameters were also obtainted.Obtained Parameters include:1,The conventional ultrasonic parameters:the right hepatic lengthes, portal vein inner diameters; the two renal lengthes and widthes, and thicknesses of renal cortexs of the two groups.2,IBS parameters:The integrated backscatter (IBS) and examined IBS% of liver and ren of the two groups were obtained .Results:1,The conventional parameters comparison : the gender,age and hepatic sizese and renal sizese had no significantly difference between groups A and B(P>0.05). 2,IBS parameters comparision:the IBS parameters of livers in A group were significantly higher than those in B group(P<0.01).According to CTC 3.0,IBS and IBS% in group A that include patients whose livers had not damaged and those patients whose livers had damaged were significantly higher than those in B group (P<0.05,P<0.01).But in A group these parameters that were compared had no significantly difference (P>0.05).the IBS parameters of rens in A group were significantly higher than those in B group(P<0.01).According to CTC 3.0 , IBS and IBS% in group A that include patients whose rens had not damaged and those patients whose rens had damaged were significantly higher than those in B group ( P<0.05,P<0.01 ) .But in A group these parameters that were compared had no significantly difference(P>0.05).Conclusions:Integrated backscatter parameters may be valuable in the assessment of hepatic and renal toxicity by symphysic chemotheraphy (Paclitaxel and Cisplatin),especially the assessment of early damage was more sensitive than those parameters from clinical laboratory.