Observasion Supplementary Effect Of N-3PUFA To Paroxetine For Depressive Disorder Of Suicide Attempters

Objective: To find supplementary effects of n-3 polyunsaturated fatty acids to Paroxetine for depression of suicide attempters.Objects and Methods:We had drawn out 39 attempted suicide patients who suffering from depression from Dalian Jinzhou District Central Hospital and Jilin psychiatric hospital during August 2005 to December 2006. 21 cases were given n-3PUFA to intervention by 3 months with random and double blind method, and 18 cases were served as control. During the intervention period, 39 attempted suicide patients had received fixed dose of antidepressant (Paroxetine 20mg/d). In the same time, HRSD (Hamilton Depression Rating Scale), BDI (Beck's depression inventory) and SIS (the Suicide Intent Scale) were evaluated respectively at baseline, then 1.5 and 3 months. Blood samples were collected from 39 attempted suicide patients at above 3 time points to fatty acid analysis.Data was input in the computer, SPSS12.0 software was used to t test, Chi-square, one-way ANOVA and Pearson correlation.Results: Firstly, how correlation existed between the depressed scores of 39 suicide attempters and the fatty acids level. Scores of HRSD positively correlated with AA, AA/EPA. Secondly, Comparison between n-3 PUFA intervention group and control group at 3 time points.â‘ Depressive state There were no significant differences between n-3 PUFA intervention group and control group on scores of HRSD and BDI at 3 time points (P>0.05).â‘¡Suicide ideation There were no significant differences between n-3 PUFA intervention group and control group on scores of SIS at 3 time points(P>0.05).â‘¢PUFA levels of erythrocyte membrane There were no significant differences between n-3 PUFA intervention and control group at baseline (P>0.05); There were significant differences between n-3 PUFA intervention group and control group on 20:5 n-3(EPA), 22:6n-3(DHA), n-3% and n-6/n-3 at 1.5 and 3 months point (P<0.05). Thirdly, Self- comparison among the 3 points of time before and after intervention.â‘ Depressive state Some significant differences were found on scores of HRSD and BDI in any one of n-3 PUFA intervention group and control group to self-comparison among 3 points of time (P<0.05).â‘¡PUFA levels of erythrocyte membrane In n-3 PUFA intervention group, some significant differences existed in 20:5 n-3(EPA), 22:5 (n=3), 22:6n-3(DHA), n-3% and n-6/n-3 at self-comparison among 3 time points (P<0.05); In the control group, no significant differences were found on PUFA levels of erythrocyte membrane at self-comparison of 3 time points (P>0.05).Conclusions:â‘ Depressed scores of 39 suicide attempters with depression are higher, AA and AA/EPA are higher.â‘¡Improving depression is equal between n-3 PUFA intervention group and control group.â‘¢Reducing suicide ideation is equal between n-3 PUFA intervention group and control group.â‘£There are no supplementary effects of n-3 PUFA to Paroxetine for depression of suicide attempters.