Relationship Between Amyloid Beta Peptide 40 And Type 2 Diabetes With Macrovascular Complications

Objective To analyze the relativity ofβ-amyloid peptide 40(Aβ40) and macrovascular complications of type 2 diabetes mellitus (T2DM).Methods 55 cases of patients with type 2 diabetes(66.0±2.4 years old), including 23 cases of males and 32 cases of females, were recruited from a group of inpatients at the First Affiliated Hospital of Dalian Medical University and the enrollment started from October to December in 2006. These patients, whose average duration was 10.7±1.3 years, without infection, ketosis, tumors, other chronic diseases and serious renal failure or hepatic dysfunction, were divided into 2 groups -T2DM with macrovascular complications group and T2DM without macrovascular complications group, along with 31 cases of healthy subjects selected as control group. The T2DM group with macrovascular complications was diagnosed by the characteristics of cardiovascular diseases, cerebral vascular diseases, or peripheral artery diseases. For the T2DM group without macrovascular complications excluding the above characteristics, additional detail condition was also met as the following: the values of conducting arteries intima-media thickness (carotid artery and iliac artery) were limited within 1.0 mm.At the time of enrollment, the data from physical examinations were collected by standards for all the subjects, including the following variables: age, gender, body mass index (BMI), waist hip ratio (WHR), systolic blood pressure (sBP), diastolic blood pressure (dBP) and resting 12-lead electrocardiogram (ECG). Fasting blood was obtained for analyses of serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), serum creatinine, glutamic-pyruvic transaminase (ALT), HbA1c and plasma glucose levels by standard laboratory techniques.Results Aβ40 level of type 2 diabetic patients increased significantly (P<0.05) compared with that of control ones. Patients in T2DM with macrovascular complications group had higher Aβ40 level than those in T2DM without macrovascular complications group (P<0.05). Moreover, the level of Aβ40 was positively correlated with waist circumference by Backwad multivariate linear regression analysis (P=0.008). Based on multiple logistic regressive analysis, FPG, TG and Aβ40 were correlated with macrovascular complications of T2DM (OR=6.061, 5.735, 1.352, and P=0.001, 0.064, 0.069, respectively).Conclusions High circulating level of Aβ40 was associated with obesity and T2DM, especially diabetes combined with macrovscular complications. Aβ40, the same as TG, waist circumference and FPG, might be the risk factors of macrovascular complications in type 2 diabetic patients and contribute to the processing and development of macrovascular complications in type 2 diabetes.