Functional Magnetic Resonance Imaging Study Of Response Inhibition In Attention-deficit Hyperactivity Disorder

Part I Functional MRI compare study of the normal school-age children and adult's response inhibitionObject Using functional magnetic resonance inaging(fMRI) to study the normal school-age children and the adult's response inhibition brain activations map by continuous performance testMethord Event-related designed BOLD functional MRI scan covering the whole brain performed on 12 right-handed school children and 12 normal adult executing continuous performance test and collect all the participants behavior data,using SPM2 to analyze the fMRI data with T-test to generate the activition map.Results : Within group analysis: (1) Normal children perform response inhibition showed activations in right cingulate cortex,left dorsolateral prefrontal cortex (DLPFC) (BA46/9),bilateralventrolateral prefrontal cortex(VLPFC),left insula and cerebellum(2)Normal adult revealed significant activations in middle prefrontal cortex(MPFC),cingulate cortex,left dorsolateral prefrontal cortex (DLPFC),left ventrolateral prefrontal cortex(VLPFC) and fusiform. group analysis (3) Comparing the two groups ,school children showed less activations in middle prefrontal cortex,dorsolateral prefrontal cortex,but children showed significant activation in right ventrolateral prefrontal cortex and cerebellum.Conclusion The normal school-age children in the implementation of response inhibition process cingulate cortex and prefrontal play an important role. The school-age child coordinates in the execution response inhibition dependence on more brains area, the experiment indicated DLPFC and VLPFC participated in the response inhibition function together .Part II Functional magnetic resonance imaging study of response inhibition in attention–deficit hyperactivity disorderObjective To study the brain activations and function station of attention–deficit hyperactivity disorder children's performance high response inhibitionMethods Event-related designed BOLD functional magnetic resonance imaging (MRI) scan covering the whole brain performed on 12 right-handed attention–deficit hyperactivity disorder children matched 12 normal children executing continuous performance test and collecting all the participants behavior data.Results Within group analysis: (1) behavior results: ADHD children's hit numbers and reaction time were lower than control group(P<0.01),missed[(6.3±4.1)] and false alarms[(3.9±2.4)] were more than control group[(2.2±1.9)(,1.9±1.0);P<0.01-0.05].(2) ADHD children showed decreased activations in anterior cingulate cortex (dACC),ventrolateral prefrontal cortex(VLPFC), caudate nucleus,and cerebellum (dACC),(p<0.05, ancorrected, voxel>20)Conclusion ADHD children's response inhibition limited,mainly dysfunction brain area were anterior cingulate cortex, prefrontal cortex, basal ganglia. and cerebellum.