| Objective To investigate the cognitive development and the brain mechanism of mental calculation of School-aged children using event-related potentials,and the effects of subclinical epileptiform discharges on mathematics cognitive function in benign epilepsy of childhood with centrotemporal spikes(BECTS).Methods One hundred and twenty children aged from 7 to 12 years old , eleven BECTS children and eleven normal children that match age, gender,years of education and family socioeconomic status with BECTS children were subjects, using simple additions , subtractions and multiplication within twenty as visual stimulus, event-related Potentials were distilled by BESA.Results (1)Response time of mental calculation decreased and the accuracies of mental calculation increased with the growth of children'age; there was significantly statistical meaning(P <0.05) for N2 and P3 amplitude among different age groups ,and they had similar trend that the amplitude decreased from seven-year-old to eight-year-old, and increased for nine-year-old and ten-year-old,then decreased again from eleven-year-old to twelve-year-old. (2)Compared with the control group, the latency of P3 was significantly prolonged and the amplitude of P3 decreaced in BECTS children group;The response time was longer in the different kinds of arithmetic operations and there were more errors in addition and subtraction in BECTS children group than in the control group.Conclusions (1)The older school-aged children are, the stronger their mental calculation abilities. N2 may be related to the retrieval of arithmetic facts, there may be a negative correlation between the amplitude of N2 and the extent reliance on direct retrieval strategy in the calculation, and a positive correlation beween the amplitude of P3 and the mental resources that children devoted to the task. (2)Frequent subclinical epileptiform discharges may be the possible factor contributing to mathematics cognitive impairment for children with BECTS.
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