| Objective:Detect the Basic fibroblast growth factor(bFGF),Matrix metalloproteinase-2(MMP-2)express levels detection in Patients's serum of nasopharyngeal carcinoma before and after radiotherapy。Discuss the correlative research for bFGF,MMP-2 in infiltraive transfer of in Patients's serum of nasopharyngeal carcinoma。Methods:bFGF,MMP-2 express levels in serum were determinded in 63 same NPC patient before and after radiotherapy by Enzyme-linked immunosorbent(ELISA),contemporary the 20 healthy check-up people were determinded。The relationshipn between the express levels of bFGF,MMP-2 in NPC patient before and after radiotherapy and different clinic stages of NPC before radiotherapy were compared。Results:1,The express levels of bFGF,MMP-2 before radiotherapy in NPC patients's serum were 5.1535±2.2745(ng/ml),164.0763±64.6049(ng/ml), higher than healthy check-up people's serum 2.1035±0.3048(ng/ml),85.7873±6.7371(ng/ml)(p＜0.01),also higher than same nasopharyngeal carcinoma afer radiotherapy 2.5141±1.2719(ng/ml),97.4158±48.6825 (ng/ml)(p＜0.01)。Although the express levels ofbFGF,MMP-2 in NPC patients's serum afer radiotherapy higher than the healthy for check-up people,there were out of statistice meaning(p＞0.05)。2,The express levels of bFGF,MMP-2 in NPC patients's serum were irrelative to sex。3,The express levels of bFGF,MMP-2 in NPC patients's serum increase with the stage of tunmor clinic and TNM stages rasing。4,The express levels of bFGF,MMP-2 have positively sensitivity relationship existed in NPC patients's serum before radiotherapy (r=0.8748,p＜0.01)。Conclusion:The resules indicated that there were definite value in detection of bFGF,MMP-2 express levels for the happen,the development,the infiltraive and the transfer of the nasopharyngeal carcinoma patients。There are some estimate value to check the express levels of bFGF,MMP-2 with combine。There are maybe some important value in diagnose,transfer and recrudesce after therapy for NPC。...
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