The Clinical Features Of Patients With Type 2 Diabetes And Colorectal Cancer

ObjectiveTo investigate the clinical features of type 2 diabetes with colorectal cancer,in order to learn more about blood glucose control,blood-fat level,tumor location,pathological type of type 2 diabetes with colorectal cancer patients.MethodsThe clinical features of type 2 diabetes with colorectal cancer were analyzed,based on a retrospective study of 76 patients with type-2 diabetes and colorectal cancer from the Sir Run Run Shaw Hospital during the year 2000 to 2006.The tumor type,tumor location and metastasis were determined through an examination of the history, operation notes,progress notes and auxiliary examination.The data was analyzed by software SPSS11.5.Results76 patients with type-2 diabetes and colorectal cancer were analyzed,accounting for 1.1%of the total 6903 inpatients with diabetes.There were 47 male and 29 female cases,with the average age of 69.41±9.17,average diabetic duration of 5.39±4.77 years, average onset diabetic age of 64.12±10.12,body mass index of 23.85±2.90kg/m~2, average triglyceride level of 1.53±0.65mmol/L,average total cholesterol level of 4.36±1.23mmol/L,and average LDL cholesterol level of 2.70±1.04mmol/L,and about 50% of the cases got hyperlipemia.There were 40 male and 25 female cases over 60 years old,and 7 male and 4 female cases less than 60 years old.The average fasting blood glucose(the first time after admission)level was 7.99±2.86mmol/L,with 18 cases having fasting blood glucose less than 6.1mmol/L and 30(39.47%)cases over 7.8mmol/L.The average postprandial glucose(the first time after admission)level was12.79±4.50mmol/L,with 7(9.72%)cases having postprandial glucose less than 7.8mmol/L and 45(62.50%)cases over 11.1mmol/L.There were 11 cases(14.5%)with ascending colon cancer,9(11.8%)with transverse colon cancer,2(2.6%)with descending co/on cancer,16(21.1%)with sigmoid colon cancer,38(50%)with rectum cancer,26 with well-differentiated adencarcinoma,4 with well-moderately-differentiated adencarcinoma,2 with moderately-differentiated adencarcinoma,2 moderately-pooly-differentiated adencarcinoma,1 with poorly-differentiated adencarcinoma,11 with mucinous adenocarcinoma,and 2 with papillary adenocarcinoma.There were 7(9.6%)Duke's A patients,26(35.6%)Dukes' B patients,22(30.1%)Duke's C patients,and 18(24.7%) Duke's D patients.And 35 patients(25 male,10 female)got lymphonode metastases. There were not much difference of lymphonode metastases between male and female patients(P＞0.05).The clinical features of type 2 diabetes with colorectal cancer:Most patients with type-2 diabetes were old when they got colorectal cancer,and had poor blood glucose control.Some patients(14 cases,accounting for 18.6%)didn't have history of diabetes, and they were not diagnosed until the examination before the operation of colorectal cancer.The colorectal cancer was found more in sigmoid colon and rectum than in other part of the large bowel,and there were not much differences between male and female patients(P＞0.05).The colorectal cancer was more likely to be well-differentiated and moderately-differentiated.Liver metastases were the main distant metastases of colorectal cancer.26(34.21%)patients had history of adiposis hepatica,25(32.89%) patients history of cholecystolithiasis,38(50%)patients history of hypertension and 16 (21.05%)patients history of polyp intestinal.49 patients were tested for stool OB,with 35(71.43%)patients showing positive outcome.21 patients were tested for carcino-embryonic antigen(CEA),with 9(42.86%)patients showing high level of CEA.ConclusionsMost patients with type-2 diabetes were old when they got colorectal cancer,and had poor blood glucose control.Some patients didn't have history of diabetes,and they were not diagnosed until the examination before the operation of colorectal cancer.The colorectal cancer was found more in sigrnoid colon and rectum than in other part of the large bowel.And there were more advanced colorectal cancer cases.Liver metastases were the main distant metastases of colorectal cancer.There was a high rate of complication of adiposis hepatica and cholecystolithiasis.