Clinical Analysis Of Chest Involved Multicentric Castleman's Disease

[Objective] To enhance the understanding about the rare chest involved multicentric Castleman's disease(MCD), decrease misdiagnosis and increase life span.[Methods] Clinical features and related information Of 5 cases of MCD were retrospectively analyzed,and clinical manifestation, imageology, pathology, differential diagnosis, therapeutics and prognosis have been discussed.[Results] There were a variety of clinical situations of the 5 cases ,with a lack of specificity.Multicentric Castleman's disease has a more aggressive clinical course with diffuse lymph node enlargement and systemic illness. Most were the plasma-cell type,and Pathology shows lymph follicle hyperplasia with a lot of plasma cells infiltration.The chest imaging showed hilar as well as mediastinal lymphadenectasis, lymphocytic interstitial pneumonitis and pleural effusion. Treatment with corticosteroid and chemotherapy can achieve partial remission. [Conclusions] Chest involved multicentric Castleman's disease has complicated clinical manifestations and is difficult to diagnose.Early, repeated and multi-location biopsies on peripheral lymphonodes and lung biopsy is important for early diagnosis. An optimal curative effect can be achieved with a suitable therapeutic option, based on histopathology and clinical classification.