Study Of Child Metabolism Syndrome In Jinan

Research backgroundMetabolism syndrome(MS)is a hot spot in recent years.MS is a group of clinical syndromes characterized as centricity obesity,hypertension,disturbance of glycometabolism and dysfunction of blood fat.In MS patients,the morbility of diabetes and cardiovascular disease is several times of that of normal people.With the development of the living standard and the change of life style,MS not only appears commonly in adults,but also begins in children.The prevalence of MS in children will harm children's health both in the near future and long term.Therefore,it's very important to grasp the morbility of MS in children and try to interfere in it.Nowadays, domestic large scale research of MS in children could hardly be seen.So,we investigated the children aged 10-12 in Jinan to get some idea of MS morbility.Research Objective1.To investigate the morbility and influencing factors of children MS in Jinan.2.To study the relationship between children MS and artherosclerosis (AS).3.To explore how to interfere in children MS and provide evidence for the following work of effective intervention.Methods 1.According to the principle of random cluster sampling,a primary school is selected randomly in different district of Jinan city and countryside nearby,count pupils of grade 4-6(aged 10-12)in each school were investigated.2649 children were studied.â‘ BMI(body mass index,BMI)was calculated by physical examination of the body height and weight,and fat and overweight children were selected according to BMI.â‘¡P₉₀of children's waistline was decided after physical examination.The blood of children with a waistline bigger than P₉₀was taken and assayed(including glutamic pyruvic transaminase,GPT;blood glucose,GLU;free fatty acid,FFA;and insulin)and ISI(insulin sensitivity index,ISI)was calculated from fasting blood glucose(FBG)and fasting insulin(FI).ISI=1000/FBG(mmol/L)×FI(μU/ml).â‘¢To aim at the possible correlation factors of children MS,a questionnaire was designed and filled in by the MS child and the parents.Then,multiplicity method was used to analyze the correlation factors of children MS in Jinan.2.MS children were designed as experiment group,and normal healthy children of the same age,sex and similar height(the difference should be less than 3cm)were selected as control.IMT(intima-media thickness,IMT),hs-CRP(high sensitivity C-reative protein,hs-CRP)and ISI were assayed and compared in both groups to get some idea of the relationship between children MS and arteriosclerosis(AS).3.According to the previous results,the nursing model of self-care was taken to interfere in the life of MS children,and the emphasis was to decrease energy intaking and to increase activity amount moderately.6 months later,BMI,WC,SBP,DBP,TG, HDL,LDL-c,hs-CRP and ISI in both groups were examined again and every index was compared with that before the intervention.Results1.In children aged 10-12,the rate ratio of overweight and obesity was separately 11.02%(male 13.67%,female 11.16%)and 12.68%(male 14.46%,female 10.71%). The morbility of MS was 3.09%(obesity children 19.35%,overweight children 5.82%,separately).The obesity morbility of the urban field was 4.98 times of that of the countryside,overweight 7.96,and MS 12.9 separately,and the difference was significant.The influencing factors of children MS in Jinan were familial inheritance history of diabetes and hypertension,frying and high carbohydrate food and little sport time.2.With the increase of MS constituents,hs-CRPand IMT increased gradually, but ISI decreased,and the difference was significant compared to control group (p＜0.05).hs-CRP increased significantly(3.73±0.28,3.98±0.46,3.90±0.75,4.02±0.63 separately,and the control group 1.13±0.43).IMT also increased significantly(0.458±0.121,0.467±0.106,0.587±0.083,0.596±0.093 vs 0.304±0.134 separately,and the control group0.304±0.134),but ISI decreased significantly (17.35±7.17,13.42±6.89,9.38±4.26,8.44±5.31 separately,and the control group 38.12±9.37).3.Each index before and after intervention.BMI(kg/m2):29.77±5.04 vs 25.15±6.48(p＜0.05);WC(cm):86.97±14.05 vs 78.38±16.16(p＜0.05); SBP(mmHg):125.97±7.73 vs 119.78±8.17(p＜0.05);DBP:72.57±9.38 vs 70.78±9.68(p＞0.05);ISI:11.59±7.12 vs 20.08±11.92(p＜0.01);HDL(mmol/L): 1.14±0.246 vs 1.67±0.280(p＜0.05);LDL-c:2.46±0.830 vs 1.95±0.494(p＜0.05); TG:1.24±0.47vs 1.19±0.57(p＞0.05);hs-CRP:2.57±0.56vs 1.38±0.25(p＜0.05).Conclusions1.The MS morbidity in children of 10-12 years in Jinan was 3.09%,which was 19.35%in obesity children and 5.82%in overweight children separately.This shows that the MS morbidity in Jinan children is quite high,to which people should pay more attention.2.This research shows that BMI,WC,high fat diet,sports habit and familial inheritance history of diabetes and hypertension were closely related to MS,among which WC and familial inheritance history of diabetes were most important.3.With the increase of MS constituents,IMT and hs-CRP increased gradually, but ISI decreased,which shows that MS in children is closely related to AS.The more the MS constituents,the easier for the AS to happen. 4.Each index of children MS could be improved by educating children to lose weight from rational diet and moderate sport,which is very important to prevent children MS.