Acidolysis Of Dihalide To Aldehye(Ketone) And Acyl Chloride

Aldehyde (ketone) has a wide variety of industrial applications, such as food additives, fragrance in cosmetics, perfumes and detergents, as well as solvent for resins,oil and other chemicals. As one of important derivatives of carboxylic acid, acyl chloride (or acid chloride) is also a key intermediate of many chemicals.In this thesis, the new synthetic routes to aldehyde (ketone) or acyl chloride using the method of acidolysis of dihalide were designed and validated. These routes can prepare not only aldehyde (ketone) and acyl chloride, but provide a new method in the synthesis of acyl chloride. Compared with the classical synthetic routes, the new one had many advantages such as the low environment pollution; high capacity of atom; high economy benefit etc.The reactions of benzyl chloride and benzoic acid to benzyl aldehyde and benzoic cholride were studied and the reaction mechanism was validated. The influence of the catalyst,reaction time and the molar ratio of reactants were also investigated. Based on the model reaction, o-chlorobenzalchloride was used instead of benzyl chloride to give o-chlorobenzaldehyde, and the reaction conditions were also optimized. Acetic acid, propanoic acid, and salicylic acid were also used instead of benzoic acid to prepare different acyl chlorides to enlarge the application of these kinds of reactions.