Study On The Laboratorial Recovery Of Rat Cervical Nerveroots Injury Treated With Manipulation Of Mechanical Vibration

Objective: Through the empirical research that to treat rats with injury of cervical nerve roots by carrying manipulation of mechanical vibration out with home-made automatic machine of manipulation, to observe curative effect and illuminate mechanism of action of it.Method: Tow hundreds and forty Wistar rats were allo- cated randomly equally to four groups that each ones had sixty rats, namely the first group being treated by manipulation of mechanical vibration, the second one being treated by injecting NGF in gluteus maximus of rats, the third one with injury of cervical nerve roots and the last one without injury of cervical nerve roots not being treated but being bred normally. In term of different time of being treated, each groups were allocated randomly and equally to five subgroups again that each ones had twelve rats, namely the subgroups of 1d, 7d, 14d, 21d and 28d. only when incision of rats already healed up after one week, we could observe gait of rats and behave in experiment of grasping ground and measuring diameter of forelimbs of them, and in the same time we could detect ex vivo starboard brachial plexus by electrophysiology and submandibular gland by the way of immunity and chemistry, and observe submandibular gland under light microscope.Results: There is marked diversity in observational index of four groups and each subgroup in three groups except the last group with injury of cervical nerve roots (P<0.05), after dealing each group with different methods and observing each subgroup in the same group and at different time in contrast. This empirical study demonstrated on the one hand that the group being treated by manipulation of mechanical vibration is preferable to the one being treated by injecting NGF and inferior to the one without injury of cervical nerve roots, and the one being treated by injecting NGF is preferable to the one with injury of cervical nerve roots not being treated but being bred normally, on the other hand, the rats to be treated the more times, injury of cervical nerve roots of them to recuperate the better.Conclusions: There is marked effect in treating injury of cervical nerve roots of rats by manipulation of mechanical vibration. It provides a reliable method to ulterior elementary empirical study of manipulation, and scientific theoretical evidence about confirming availability of treating cervicalspondylotic radiculopathy by manipulation in clinic.