Relationship Between The Level Of Serum ACA And β-HCG In Patients With Pathological Pregnancy And The Neonate's Condition

Objective To study the level of anti-cardiolipin antibodies(ACA)and beta-Human chorionic gonadotropins (β-HCG)in serum of gravidas with premature delivery, premature rupture of membrane and pre-eclampsiaon late pregnancy stage and the relationship between their level and the neonate' s condition in order to search for the clinical value.Methods ACA andβ-HCG in serum were evaluated in 136 health women,including 30 normal pregnancy(group A)and 106 pathological pregnancy(group B).Group B include group B₁(30 tPROM);group B₂(18 premature labor);group B₃ (22 pPROM)and group B₄(36 eclampsism).The level of ACA andβ-HCG was measured by enzyme linked immunosorbent assay(ELISA)and electrochemi luminescence immunoassay (ECLIA),and the comparison of neonate' s condition was performed.After parturition,we studied the placenta and compared the diference between group A and group B.Results ACA andβ- HCG level in serum of gravidas with premature delivery,premature rupture of membrane and pre-eclampsia was significantly higher than that of normal gravidas(P＜0.05).Neonate' s weight,length and Apgar score in normal gravidas had significant difference with those of premature delivery,PROM and pre-eclampsia (P＜0.01).In group B,gravidas have significant placentopathy and neonatal disorder when ACA andβ- HCG level in serum were higher than two times of median.Conclusions The level of ACA andβ-HCG in serum of gravida can be used as indexes to predict pathological pregnancy.They are also sensitive indexes for reflecting abnormal placenta function and affect neonate' s growth.