Effect Of XFN-V On TXA₂ And PGI₂ In Blood Plasma Of Acute Myocardial Ischemia Rats Caused By Injecting Pituitrin

Objective: To observe the effect of XFN-V on TXA2 and PGI2 in blood plasma of acute myocardial ischemia rats caused by injecting pituitrin.Methods: 60 Wistar rats were divided into 6 groups at random: normal control group, model control group, high dosage XFN-V group(17.08g/kg),Middle dosage XFN-V group(8.54g/kg),low dosage XFN-V group(4.27g/kg),positive control group (ISMN).Intragastric administration was adopted once a day for 14 days. Acute ischemia model rat was established by injecting pituitrin from sublingual vein 30min after the last administration, and blood plasma was separated to be determined the activity of TXB2 and 6-Keto-PGF1a that is the metabolite of TXA2 and PGI2 in blood plasma.Results: Having been injected pituitrin, the activity of TXB2 upgraded (P<0.05) while 6-Keto-PGF1a decreased (P<0.05 or P<0.01).Compared with model group, XFN-V (17.08g/kg, 8.54g/kg) group could decrease the activity of TXB2 (P<0.01).Conclusion: One of the action mechanisms of XFN-V ameliorating myocardial ischemia caused by pituitrin is that it can increase the ratio of 6-Keto-PGF1a /TXB2 through decreasing the activity of TXA2.