The Anti-malarial Activity Of Ginsenoside

Malaria is still one of the major health problems in the world. Ginseng roots is regarded as a miraculous herb in China. The present work was to investigate the effects of the ginsenosides and the protopanaxadiol on the antimalarial activity. Early and residual malaria infection in vivo was investigated using mice of 4-6 week old and weighing between 18-22g, at the dose ranging from 5 to 50mg/kg per day.The ginsenosides exhibited detectable currative activity at the doses of 50mg/kg, when the mice were fed with the ginsenosides orally for 6 and 8 days, the percentage chemosuppression of malaria was 53.12% and 57.52%, respectively with (P<0.01. The protopanaxadiol exhibited detectable curative and preventive activity on malarial, at the dose ranging from 5 to 50mg/kg per day, when the mice were fed orally for 4 days, the curative rate of the protopanaxadiol was maximum in this early test with 46.97% chemo-suppression at 50mg/kg day. But when the mice were fed orally for 6 days, the cure rate was decrease. In preventive test at the doses of 10mg/kg, when the mice were fed with the protopanaxadiol orally for 6 and 8 days, the percentage chemosuppression of malaria was 41.22% and 35.49%, respectively (P<0.01). At the doses of 50mg/kg, the result of the in vivo evaluation of the the extract on residual malaria infection showed a consistent increase in chemo suppressive activity.