| Objective: To explore the correlation between HCC relevant factors such as AFB1 exposure,HBV infection,corn-intake,alcohol-drinking etc. and the phenomenon of HCC family-clustering in GuangXi populations who are at high risk for HCC.Methods:(1) Choose 12 families(108 memberships) which are at least 2 cases of HCC distributing in 3 generations as high-incidence of HCC family at high incidence village of HCC in GuangXi. at the same time choose 12 families (126 memberships) at the same village as control. (2)A11 of the participants were personally interviewed based on a structured questionnaire. Information obtained included corn-intaken,cigarette smoking,alcohol drinking,and personal and family history of major diseases etc. (3) Drawn 10ml peripheral blood to detect the biomarker of HBV infection by ELISA and determine the concentration of AFB1 in serum by HPLC.Results: (1)The detection rate,the mean,the maximum and the standarddeviation of AFB1 in high -incidence family is 95 %,6.94 ng/ml,1.17ng/ml,0.72 respectively, and these index of AFB1 in control family is 90%,8.55ng/ml,1.88ng/ml,0.85 respectively. the differences is significant(t=3.732,P<0.001) .(2) There is difference between the rate of HBV positivity 31.48% (34/108) in high-incidence family and those 12.17% (16/126) in control family, the difference is also significant(x~2= 12.21, P<0.001).And the OR for HCC is 3.159 (95%CI= 1.627-6.132) for subjects in high-incidence family compared to those in control family .(3) The results of non-condition logistic regression analysis show that the major risk factors of the familial clustering of HCC could be listed as corn-intaken,HBsAg positive. to our surprise, the concentration of AFB1 in serum is not the risk factor.Conclusion: Corn-intaken (exposure heavily to AFB1),HBsAg positive and the difference of biotransformation to AFB1 varying from individual genotype of the two groups may associate with the familial clustering of HCC in GuangXi people who are at high risk for HCC. |
PDF Full Text Request