The Clinical Study Of The Therapy Of Xanfeitongfu To Treat SIRS And Sepsis

PurposeThis is the first research of MODS from the theory that "intestinal activated mechanism" and "lung activated mechanism" , based on Chinese medicine theoretical basis of "the lung and colorectal exterior" for the argument, using randomized controlled methods, the application of the MaXingShiGanTang and DaChengQiTang XuanFeiTongFu, early interdicting SIRS/Sepsis progress to MODS by the two activate links, disrupting the incidence of sequential of MODS, combatting SIRS/Sepsis progress to MODS to the further evolution of progress, and using clinical epidemiology and mathematical statistical methods, discussing the effect of XuanFeiTongfu theropy treating SIRS/Sepsis and its blocking SIRS/Sepsis developing into MODS.MethodChoosing patients which Western medicine diagnosis are SIRS/Sepsis and TCM is Feire symptoms/Fushi symptoms as observation of objects, using forward looking and single-blind randomized controlled study methods. All cases are 40, of which nine cases are the control group, 10 cases are the Feire group, 10 cases are the Fushi group, 11 cases are the Feirefushi group. The control group using conventional Western medicine treatment, the test groups using the conventional Western medicine treatment and also Chinese medicine on the basis of syndrome:Feire group using MaXingShiGanTang, Fushi group using DaChengQiTang, Feirefushi group using the both. Treatment for 72 hours. Through the temperature, WBC.APACHEII score, PCT, IL-6 and TNF-αbefore and after treatment in contrast observation, discussing the effect of XuanFeiTongfu theropy treating SIRS/Sepsis and its blocking SIRS/Sepsis developing into MODS.ResultThe differences of APACHEII score, PCT, IL-6, TNF-α, temperature and WBCbetween treatment group and control group before treating were notstatistically significant(P>0.05). Three days after treatment, Feiregroup, Fushi group, and Feirefushi group's APACHEII score,IL-6 level and WBCdrop by more than the control group, the difference was significant(P<0.05);Feire group, Fushi group, and Feirefushi group's PCT levels comparedwith the control group had tatistically significant difference(P<0.05). Feiregroup, Fushi group and Feirefushi group's TNF-αlevels and body temperaturechanges compared with the control group had no statistically significantdifference (P>0.05). The incidence of MODS and mortality between the fourgroups, there was no significant difference(F>0. 05).ConclusionThe decline of APACHE II score show that XuanFeiTongfu therapy can effectively prevent drug accumulate in the lung and intestinal evil in the build-up, indirectly, that XuanFeiTongfu therapy to be effective in blocking MODS through the two key activate links—"intestinal activated mechanism" and "lung Activated mechanism" . which can block SIRS/Sepsis developing to MODS. XuanFeiTongfu therapy can effectively reduce the level of PCT, to reduce the extent of the infection, and improve the prognosis of patients. XuanFeiTongfu therapy can effectively reduce the level of IL-6, showing that XuanFeiTongfu therapy can effectively block cytokine cascade, to stop the continuous expansion of inflammatory response and prevent extensive damage cells, so as to reduce the patient's condition and improve the prognosis. To sum up, XuanFeiTongFu therapy can reduce the extent of infection in patients with sepsis, reducing pro-inflammatory cytokines and the media release, controling cytokine cascade, so as to reduce the systemic inflammatory response syndrome and the serious sepsis, blocking SIRS/MODS to the development of MODS.