The Clinical Safety Of Aconitum Carmichali Debx

ObjectiveThe problem intends to use zhe principle and method of Pharmaco Epidemiology, correlativity estimating that the praeparata clinical practice security of Aconitum carmichali debx, first step make factors and security such as whose clinical accommodation , usage , dosages and making medicines compatible' s clear objectively. Guide Aconitum carmichali debx praeparata clinical practice to provide scientific basis for sth by the fact that the problem studying , being, security provides a basis to the clinical practice appraising deleterious traditional Chinese medicine rationally.MethodIn this study, by following the principles and methods of Pharmaco Epidemiology. A descriptive analysis was done for counting the frequency of the TCM syndromes, dose, administration methods, recipe matching, adverse reactions, potentially influential factors and detoxification methods, which are the relevant indexes for the clinical application of aconitum carmichali debx.Result159 examples collecting case in total, great majority of traditional Chinese medicine discriminate the be a false cold certificate or overcast cold certificate when using Aconitum carmichali debx praeparata clinically result display. Aconitum carmichali debx praeparata' s minimal dosages are 3 grams , maximal dosages are 40 grams , in common use dosages are 15 grams. Fry 354 time of person among them first , fry 7 time of person together. Decoct time for 90 minute case is 225 examples more than normal comparatively. Aconitum carmichali debx praeparata and licorice root making medicines compatible the most , are 298 time, be that Radix aconiti praeparata matches 182 time of dried ginger secondly.Among 117 example follow-up case, the bad event appears 3 examples. The have pins and needles in for argument , nauseated and vomity , nervous palpitation of reactive bad 3 example Aconitum carmichali debx praeparata behaviour type, appears within 30 minutes without exception behind taking medicine , short person of sustained time is 3 minutes , the senior may amount to 6 hours. 3 average dosages of example case middle Aconitum carmichali debx praeparata of bad event appears for 21. 23 grams , maximal dosages are 30 grams; Aconitum carmichali debx praeparata's average dosages are 16.14 grams among 114 bad event of example nothing case , maximal dosages are 40 grams; Compare two set classical prescription difference analysis, difference has no notable significance (P = 0.34). 3 example case of bad event appears to fry first with medicine equally equally , Aconitum carmichali debx praeparata decocts time being 90 minutes; And have and roast licorice root , dried ginger , Asarum sieboldii making medicines compatible equally.Reactive bad Aconitum carmichali debx praeparata influencing factor, had analysed display possibility and dosages decocting time lack , making medicines compatible greatly, not thinking that the medicine certificate is inconsistent, relevant. In the light of "bad Department of Health medicines and chemical reagents reaction supervises the cause and effect relation judgment standard " that centre works out, the case developing the bad event in 3 examples carries out cause and effect relation judgment , the event pointing out that 1 example is bad is related to Aconitum carmichali debx praeparata affirmatively; 2 bad example events may be connected with Radix aconiti praeparata.ConclusionFactors influencing the clinical safety of aconitum carmichali debx include overdose, and inappropriate processing, which indicates the quality of literature for Chinese herb need to be improved, since there might be bias in the publishing. It also implies the clinical research literature for Chinese herbal formula should be improved, especially in those with poisonous Chinese herb and those with special processing methods. A good report should include the specific TCM syndrome, the method of proper usage, the dosage, the processing method and the appropriate time of boiling, the occurrence of ADR, the time of ADR, the manifestation of ADR and its influential factors etc. The literature should avoid publishing bias, and serve as reference for further systematic review study, in order to provide valuable information for the evaluation of clinical safety for poisonous Chinese herb medicine.