The Clinical Study On "the Method Of Jianpi Zishen Huoxue" For Intervention Of Impaired Glucose Tolerance

The IGT public is the most important public of high risk of type 2 diabetes mellitus,It is significant of the IGT intervention,the IGT stage is the vital occasion of prevention of type 2 diabetes mellitus, the IGT intervention is the important method of prevention of type 2 diabetes mellitus.Impaired glucose regulation(IGR)have three clinical types:impaired fasting glucose(IFG),impaired glucose tolerance(IGT), combination of IFG and IGT.The most famous clinical trial of the IGT intervention by Western Medicine include that Acabose for prevention of type 2 diabetes mellitus(STOP-NIDDM),the Diabetes Prevention Program (DPP),TRIPOD and PIPOD,Nateglinide for prevention of type 2 diabetes mellitus,Orlistat for prevention of type 2 diabetes mellitus,et al, they have notably clinical effection in some constant,but their curative effect of prevention limited because of side-effect and high-price.IGT belong to the Chinese medicine category of Xiao-ke,the pathogeny and mechanism include that deficiency of yin,deficiency of spleen,dry heat,liver stagnation,conbination phlegm and stagnation, et al,the main treatment consist of tonifying spleen,nourishing kidney, extending liver,et al.The IGT intervention by Chinese medicine has few side-effect,low -price and well- compliancy,it can remarkably improve insulin tolerance,protectβcell of pancreas,evidently increase the quality of life.Objection:To study the therapeutic effect and discuss the method of Jianpi Zishen Huoxue decoction(Yitang decoction)on impaired glucose tolerance.Method:120 cases of IGT were randomly allocated to three groups:40 cases treated with Acabose served as western medicine control group,40 cases treated with no medicine served as blank control group,and 40 cases treated with Yitang decoction as chinese medicine treatment group,three groups dealed with compatible diet and exercises.The treatment course last one year,six months per course.Beofore and after treatment, detected the index of weight,lipid,glycosylated hemoglobin(HbA₁c),oral glucose tolerance test(OGTT),blood serum insulin,insulin sensitivity index(ISI) Result:The levels of two-hour postprandial blood glucose(2hPBG)in the chinese medicine treatment group and western medicine control group were decreased significantly than blank control group(p＜0.01);The levels of blood serum insulin in the chinese medicine treatment group and western medicinecontrol group were increased evidently than blank control group (p＜0.05);The levels of insulin sensitivity index(ISI)in the chinese medicine treatment group and western medicine control group were increased obviously than blank control group(p＜0.05),the levels of insulin sensitivity index(ISI)in the chinese medicine treatment group were increased markedly than western medicine control group(p＜0.05); The rate of transform IGT to DM or IGT maintenance in the chinese medicine treatment group and western medicine control group were lower visibly than blank control group(p＜0.05),and no differences between the chinese medicine treatment group and western medicine control group(P＞0.05), the rate of transform IGT to NGT in the chinese medicine treatment group was 79%.Conclusion:Jianpi Zishcn Huoxuc decoction(Yitang decoction)can promotcd distinctly glucose tolerance,lipid,insulin sensitivity,and was superior to western medicine control group,revealed that Yitang dccocdon can improved insulin resistance and secretion ofβpancrea cell,and in favor of the IGT reversion to NGT.