| Objective:To study the relationship between the degree of liver fibrosis and the serology target and ultrasonic inspection in patients of hepatic disease which have different cause. To verified the effect of FibroIndex. Methods:we have total 111 patients with different causes of hepatic disease. Determine the serum alanine amino-transferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) andγ-glutamyl transpeptidase in enzyme (GGT), total bilirubin (TBIL), albumin (ALB), globulin (GLO), platelet (PLT), prothrombin time (PT), serum procollagen typeⅢ(PCⅢ), hyaluronic acid (HA), laminin (LN), collagen typeⅣ, used ultrasound examination and at the same time we do liver puncture biopsy to diagosis the liver fibrosis stage, analysis the relationship between them. According to 70 patients with chronic hepatitis B patients with serological indicators of platelet (PLT),γ-glutamyl transpeptidase in enzyme (GGT), hyaluronic acid (HA) and age four indicators of liver fibrosis index, the control evaluation of pathologic diagnosis its diagnostic value. Result: There was no significant difference between the Ultrasound diagnosis in determining the extent of liver fibrosis and the pathological judgments, The rates of consistent between ultrasound diagnosis and pathology in light, moderate and severe stage of liver fibrosis is 58.97%, 33.93%, 50.0%. Serum albumin, globulin, platelet, prothrombin time, procollagen typeⅢ(PCⅢ), hyaluronic acid (HA), collagen typeⅣin different stages of liver fibrosis have a statistical difference, and platelets Albumin and liver fibrosis were negatively correlated, prothrombin time and time globulin and liver fibrosis were positively correlated, serum procollagen typeⅢ(PCⅢ), hyaluronic acid (HA), collagen typeⅣlevels and liver fibrosis was positively correlated. As a non-invasive diagnostic method the sensitivity of predictive model is 61.11%, specificity is 94.12%, to judge obvious liver fibrosis with≥S3 and >3.0 in the diagnosis of community. Using receiver operating characteristic curve analysis, the area under the curve Az = 0.8476, the standard error Se = 0.0466, 0.70 |
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