Study Of Treatment On Allergic Rhinitis With Asthma By Different Ways Of Inhaling Corticosteroids

Objective: To observe the clinical effect of treatment on allergic rhinitis with asthma by different ways of inhaling corticosteroids. Methods: 90 cases of patients suffered from allergic rhinitis with asthma were classified into three groups in random and treated with budesonide (BUD) by nasal spay, inhaling and nasal spay-inhaling combined administration for 12 weeks, respectively. The concentration of serum total IgE, ECP and IL-5, pulmonary functions were examined before and after treatment. Results: The symptom scores of rhinitis and asthma in three groups were significant improvement (P<0.05). The concentration of serum TIgE, ECP and IL-5 of three groups had decreased greatly after treatment (P<0.05). There were significant improvement in FEV₁, FEV₁/FVC% and FEF_25-75 in inhaling and nasal spay-inhaling combined groups (P<0.05) and the significant difference of FEV₁ among the three treatment groups was observed. Conclusion : The symptoms of rhinitis and asthma in three groups by three ways of inhaling BUD were greatly improved and there were no significant variation in symptom scores and serum parameters. The combined administration of BUD could improve pulmonary functions rapidly and resulted in a greater reduction in asthma-related morbidity.