Effects Of Zingiber Officinale Rosc On Inflammatory Cytokine And Adhesion Molecules In Brain Tissues Of Rat With Cerebral Ischemia Reperfusion

[Objective] To observe the change of inflammatory cytokines and adhesion molecules content after cerebral ischemia/reperfusion (CIR) and the effect of aqueous extract of ginger.[Methods] Male SD rats were evenly randomized into sham-operation, model, nimodipine, aqueous extract of ginger groups. CIR model was produced by Pulsinelli's"Four Vessel Occlusion"method. The contents of inflammatory cytokines including interleutin-1β(IL-1β),interleutin-6(IL-6),interleutin-8 (IL-8) and tumor necrosis factor–α(TNF-α) and adhesion molecules including intercellular cellular adhension molecule (ICAM-1), vascular cellular adhension molecule (VCAM-1), endothelium selectin (E-selectin) and platelet selectin (P-selectin) in brain tissue were detected by enzyme-linked immunosorbent assay(ELISA). [Results] Compared with sham-operation group, the contents of TNF-α,ICAM-1and P-selectin in brain tissue of model group increased significantly (P<0.05) . While compared with model group, aqueous extract of ginger could decrease the contents of TNF-α,ICAM-1 and P-selectin in brain tissue(P<0.05～0.01), but no significant difference to the content of IL-1β,IL-6,IL-8, ICAM-1,VCAM-1 and E-selectin, compared with model control group.[Conclusion] The therapeutic action of aqueous extract of ginger on cerebral ischemia reperfusion can be realized by decrease the inflammatory response induced by cytokines and adhesion molecules.