| There are many types of fungi in the natural world, the majority of them are useful for human beings, but a small number of fungi infect human being (or animal) and cause fungal disease.To understand the pathogenic fungi and changing in composition of strains, we studied part of culture pathogenic fungi from 2001.6 to 2007.12 in order to find changing in composition and comparing with culture pathogenic fungi from 1986-2001.Methods:The sample was identified by microscopy. The fungi were cultured and strains were identified by culturing the sample with positive patients on Sabouraud's on medium.Rusults:1081 fungi were insolated including nine strains.First, Dermatophytes 790 strains, Trichopyton rubrum (586 strains), accounting for 54.2% of isolated strains, and it is still mainly pathogens in superficial mycosis. Trichopyton rubrum is mainly cause tinea cruris (162 cases), there are 80.6% tinea cruris caused by trichopyton rubrum, the second one is tinea corporis ( 125 cases), there are 55.9% tinea corporis cause by trichopyton rubrum. Other fungal diseases are tinea pedis,onychomycosis, tinea capitis, hand tinea and ringworm of beard according to a number order from high to low rates. Secondly, Candida albicans (173 strains) that were accounted for 16.0% of the isolated strains are the second pathogenic species of dermatomycoses. Candida albicans are not only cause skin candidiasis but also other dermatomycoses, such like onychomycosis, candida albicans were isolated 61 strains in 178 cases with onychomycosis, accounting for 34.3%. The third one is ringworm hair trichophyton mentagrophytes(128 strains), accounting for 11.8% in isolated strains. Ringworm hair trichohyton mentagrophytes cause different type dermatomycoses. After that, isolated strains are sporthirx schenckii (91 strains), accounting for 8.4%; microsporum cnais(47 strains), accounting for 4.3%; aspergillus niger(18 strains), accounting for1.7%; microsporum gypseum(17 strains), accounting for 1.6%; epidermophyton floccosum trichophyton mentagrophytes(12 strains), accounting for 1.1%; aspergillus fumigatus(9 strains), accounting for 0.8%. Trichophyton rubrum is the highest rate in isolated strains, and also it is the first one both causing types of dermatomycoses and top numbers of cases. The second one is candida albicans, it is not only cause skin and mucosa candidiasis and also cause onychomycosis and other dermatomycoses. Microsporum cnais and microspoum gypeum are significantly reduced thean before. Aspergillus was isolated from onychomycosis. Recalling superficial fungal disease in northestern region and history of isolated pathogenic fungi, tinea capitis and yellow tinea had the highest incidence before liberation, microsporum rust color was mainly pathogens. We still found yellow tinea in Jilin province until 1960s. We didn't find yellow tinea in 1980s and microsporum rust color disappeared. The results showed the pathogens of superficial fungal diseases in Jilin province from 1986 to 1990; the isolated rates of trichopyton rubrum was the highest, accounting for 73.5%; the second one was ringworm hair trichophyton mentagrophytes , accounting for 12.8%; The isolated rates of microsporum cnais was 9.1%, it was third one; In late 1990s, superficial fungal disease in Jilin provence had high incidence than 1980s, suck as hand dermatomycoses and onychomycosis.Composition of species was also changed. The isolated rates of ringworm hair trichophyton mentagrophytes and epidermophyton floccosum trichophyton increased year by year, but the isolated rates of microsporum cnais reduced year by year, accounting for 14.9% to 2.5% from 1980s to late 1990s.The strains of pathogens had a big changing in tinea capitis according to isolated pathogens from different fungal diseases. The isolated rates of Trichophyton rubrum in tinea capitis increased, accounting for 10.6% to 77.3% from late 1980s to late 1990s. In reverse order,microsporum canis was mainly pathogens, it's isolated rate was accounting for 84.3% in late 1980s, but it's isolated rate was reduced to 9.6% in late 1990. Ringworm hair trichophyton mentagrophytes and epidermophyton floccosum trichophyton increased and microsporum canis reduced year by year in hand tinea, tinea pedis, tinea corporis and tinea cruris. Candida albicans and aspergillus increased and becomed mainly pathogens in onychomycosis, and isolated rate of trichopyton rubrum was reduced slowly. The isolated rate of microsporum canis was high in late 1980, especially in tinea capitis. It's possible for the reason is that many families had pets-cats. It was very popular for praise cats in some cities in Jilin provience, sush like Changchun in that time. It had a very high rate of microsporum canis in tinea corporis and tinea capitis in the families that had cats. The isolate rate of microsporum canis was reduced significantly in late 1990s. Conclusion:1. In this paper, men were slightly more than women in both with fungal diseases in 1081 specimens. There are large gender differences in a few fungal diseases, men were more than women in tinea corporis, and women were more than men in onychomycosis.2. Certain kinds of pathogens has not a definite relationship with gender of patients who with fungal disease by them.3. Isolated rate of trichophyton rubrum was the highest in 1081 specimens, the second one was candida, ringworm hair trichophyton was the third one. Isolated rate of microsporum canis and microsporum gypseum was decreased signigicantly. Opportunistic pathogen-aspergillus was isolated from onychomycosis, and also sportrix shenkii was isolated.4. This paper findings confirm that candida species in pathogenic fungi rose to second place, and aspergillus niger was isolated from onychomycosis. So there are changing in pathogenic species of some dermtomycosis past six years in Jilin province.To sum up, our clinical workers should pay full attention to culture, isolation and identification of pathogens of fungal diseases, in particular the situation about pathogen species changes, at the same time, we should pay more attention to opportunistic infection fungi and fungal diseases cause by them. Clinical doctors should take fully into account the condition with fungal and opportunistic fungal infection when they treat special patients, such like immunocompromised patients. And the doctors should also take into account whether the patients with fungal disease have immune defects, and other autoimmune conditions. It's very important for us to know and understand fungal pathogens and changing, and it has guiding significance for clinical doctors to diagnose and treat fungal diseases.
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