| Objective:1.To analyse the incidence of Gestational Diabetes Mellitus(Gestational Diabetes Mellitus , GDM) and its effect on the pregnancy outcome.2. To analys the influence of the normalized management in patients with gestational diabetes mellilus on health of mothers and their neonatesMethods:1. To analyse the risk factor of 129 cases of singleton pregnancy patients with GDM by logistic analyse method in jinan maternal and infant health care hospital in 2006, 1～2006, 12.2. A retrospective analysis about the outcome of mothers and their neonates was performed on 129 cases of singleton pregnancy patients with GDM and its control group in out-patient of Maternal and Child Health hospital of Jinan from Jan 2006 to Dec 2006 , to compare the outcome of mothers and their neonates between GDM group and its controls, to analyse the effect of GDM on mothers and their neonates.3. 129 cases of patients with GDM had been divided into two groups , the normalized treatment group and not received treatment group , according to their experience of the treatment during pregnancy. The GDM cases was match the controls. To analys the influence of the normalized management in patients with gestational diabetes mellilus on health of mothers and their neonatesResults:1. the risk factor of GDM: The incidence rate of 50g glucose challenge test (50g glucose challenge test, 50g GCT) was 5. 50% (337/6125), the incidence rate of GDM was 2. 11%(129/6125). the major suspect risk factor of GDM by turns were progestational body mass index (body mass index , BMI ) , body weight, family history, age.We had a layering analyse on age and BMI farther step , the average delivery age of normal glucose group , GIGT group and GDM group dispayed a rise tendency. The result had a statistical significance (F=33. 80, P<0. 01). The morbid risk of higher BMI group was rised than lower BMI group, Its OR value was 3.44 when BMI>24(P<0.05).2. The effect of GDM on the pregnancy outcome: We compared the outcome of GDM group to normal glucose group using chi-square test . The result displayed that the incidence rate of complication including hydramnion, premature rupture of membrane, caesarean section, premature delivery, shoulder dystocia in GDM group was higher than normal glucose group. The result had a statistical significance (respective P<0. 01). But there was no significant difference in the other complication including fetal distress, eclampsism, postpartum hemorrhage between two groups. The outcomes of infant were compared also, we found that there were significant difference (respective P<0. 01)on the outcomes including large for date infant , Neonatal hypoglycemia, neonatal asphyxia, but no significant difference (P>0.05) on low birth weight infant and hyperbilirubinemia of newborn between two groups.3. 129 cases of patients with GDM had been divided into two groups , the normalized treatment group and not received treatment group , according to their experience of the treatment during pregnancy. The GDM cases was match the controls. The common outcomes of mothers and their neonates in three groups were compared found that the Incidence rate of eclampsism, PROM, premature delivery, caesarean section, fetal distress, postpartum hemorrhage were higher in not received treatment group than that in controls group, But there were no significant difference between the normalized treatment group and the control group. On aspect of newborn infant outcomes , the fetal age was shorten in the normalized treatment group and not received treatment group than that in the control group (P<0.01, t=2.88 ; P<0.05, t=2.21) . newborn infant birth weight (t=2. 87, P<0. 05) and the incidence rate of the infant complication in the not received treatment group , including large for date infant(x~2= 13.2, P<0.01), low birth weight infant (x~2=4.21, P<0.05), neonatal asphyxia(x~2=6.93, P<0.01), Neonatal hypoglycemia( x~2= 4. 31, P<0.05), were higher than that in the normalized treatment group.Conclusions:1. the major suspect risk factor of GDM by turns were progestational body mass index, body weight, family history and age.2. GDM had obviously influence on pregnancy outcomes, it ould rise the incidence of hydramnion, premature rupture of membrane, caesarean section, premature delivery, shoulder dystocia . It could increase the incidence of the newborn infant complications including large for date infant, low birth weight infant, neonatal asphyxia, Neonatal hypoglycemia3. The normalized management for patients with GDM could effectively prevent the complication of mothers and their neonates...
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