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The System Evaluation For Albendazole Treatment Of Cystic Hydatid Disease

Posted on:2009-12-09Degree:MasterType:Thesis
Country:ChinaCandidate:C J LiFull Text:PDF
GTID:2144360242499706Subject:Surgery
Abstract/Summary:PDF Full Text Request
Objective To evaluate the quality of strictly on the basis for albendazole Hepatic echinococcosis of a systematic evaluation of clinical efficacy. Methods The compu- terized retrieval and manual retrieval, albendazole treatment HCE comprehensive collection of random and semi-randomized controlled trials, recommended by the Cochrane Collaboration Methods for Meta-analysis RevMan4.2.2. Results three test standards into line with its methodological quality rating are "B" class. A comparative study of the albendazole and mebendazole treatment HCE efficacy results showed that the number of cysts of the number of cases and efficient, there was no statistically significant difference between the two groups [RR1.19, 95% CI (0.97 , 1.46); RR 1.35,95% CI (0.91,2.00)]. Another study compared the joint operation with simple albendazole treatment HCE efficacy results showed that albendazole treatment and surgery in January to direct surgical treatment compared the difference was not significant [RR 1.63,95% CI (0.90 , 2.93)], albendazole treatment and surgery in March to direct surgical treatment had a significant difference [RR 1.89,95% CI (1.09,3.29)]. Finally a study showed that the emulsion albendazole tablets and the cure rate and the recent long-term cure rate had a significant difference, respectively [OR = 0.22,95% CI (0.08,0.57)] and [OR 0.81,95% CI = (0.33,0.73)]. Conclusions 1. Albendazole and mebendazole treatment efficacy similar HCE 2. Albendazole treatment and joint surgery compared to treatment with surgery alone, albendazole treatment course should be long enough (three months) will be show the superiority of combination therapy, 3. albendazole tablets effective than the emulsion. However, the evaluation system included in the pilot and a few small number of cases, not a comprehensive measurement indicators, it will affect the strength of the above conclusions. HCE to determine the effectiveness of albendazole treatment will be needed to carry out more high-quality tests.
Keywords/Search Tags:Hepaticcysticechinococcosis, Albendazole, Mebendazole, Evidence Based Medicine, Meta-analysis
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