Study On Assessment Of Left Ventricular Function And Postsystolic Shortening Among Hypertrophic Cardiomyopathy Patients Via Quantitative Tissue Velocity Imaging (QTVI)

Objective Hypertrophy cardiomyopathy(HCM) is a primary myocardial inappropriate disorder which often concomitance with an autosomal inheritance disease.It has a great deal of clinical manifestation and prognosis.And sudden death,heart failure,and embolis msdue toatrial fibrillation and so on is the clinical consequences.Systolic and diastolic function of sphincter muscle reduces in vent ricular septal and posterior wall among patients with hyper trophic cardiomyopathy.At first of the disease,the left ventricular ejection fraction did not reduce;even enlarge,so the development of the disease could not be controlled by clinical doctors.So,it is very important to estimate the systolic and diastolic function of hypertrophic cardiomyopathy for the HCM patients. The technique of Quantitative Tissue Velocity Imaging(QTVI) can note and measure the systolic and diastolic function of the regional myocardium directly,precisely and exactly,and it also provides further information for assessment of regional and global cardiac function among patients with hypertrophic cardiomyopathy.QTVI was to estimate the regional amyocardial function,analyze the position and lasting time of the postsystolic shortening(PSS),find the ultrasonic manifesta and diagnose standard of estimating the forepart myocardial ischemia and discuss the criterion of myocardial ischemia and time. Methods 36 HCM patients were selected as the HCM group and 40 normal persons was selected as the control group.The targets for measuring were LVEF(measured by Simpson's method),Regional systolic(Vs),early diastolic(Ve),end diastolic(Va), Ve/Va,place of PSS,postsystolic shortening velocities(Vpss) and postsystolic shortening time(Tpss).Results The parameters of systolic velocity(Vs),early diastolic velocity(Ve) and early systolic velocity/later diastolic velocity(Ve/Va) of the HCM group were significantly lower than those of the control group,while later diastolic velocity(Va) had no statistic difference between the two groups;the LVEF of the HCM group was very high,it had statistic difference compared with the normal group.In the control group,there were 162 PSS in 720 segments(22.5%);in the HCM group,there were 436 PSS in 648 segments(67.3%).The peak velocities of pathologic PSS in the HCM group were high comparing with the control group(1.90±0.49 cm/s vs 0.72±0.17)cm/s and the lasting time were long comparing with the control group(106.18±10.15ms vs 33.92±9.26ms),the difference had statistics significance.The peak velocities and the time showed statistic difference between the HCM groups and the control group(P＜0.05);the peak velocities and the time of PSS showed no statistic difference between the HCM groups and the control group,except the anteroseptal and posteroseptal walls.Conclusion Hypertrophic cardiomyopathy decreased in left ventricular function.The peak velocities of systolic and diastolic were significantly higher in HCM group than in control group,and they were higher in middle than in apical-segments.There are more PSS segments in HCM group,the peak velocities became higher and the time became longer compared with the control group.The sensitivity of ischemic myocardium was 100%and the speciticity of ischemic myocardium was 92.5%when the peak velocity was more than 0.78cm/s.the sensitivity and the speciticity of ischemic myocardium was 100%when the time more than 25.55ms.QTVI can be used to understand the mechanism of PSS,guide clinical diagnosis and supervise the therapy...