| A clinical investigation and analysis of 2250 hospitalized patients with systemic lupus erythematosusObjective The objective was to analyse the tendency of dieases changing, diagnosis, circumstance of treatment and factors influencing death, then providing epidemiology evidences to formulate measures for cure & control systemic lupus erythematosus.Methods An retrospective study was performed to analyze 2250 hospitalized patients with SLE in two hospitals from 1997 to 2006, general information, pathogenetic condition, hospital condition, treatment condition and etc were also collected.Results The ratio of male to female was 1:10.9;the median course was 4 months, and inter-quartile range was 0~24 months; age of onset range from 5~82 years old, average age of onset was 32.04±12.05; patients were mainly from countryside, accountting to 59.6%, farmer is the maximum occupation among these patients, achiving to 48.9%. There was an increasing number of hospitalized patients during the period of 1997~2006, the hospitalized patients in 2005 grew about 180% according to 1996. Department of rheumatism, department of kidney and departmrnt of dermatology remain were main clinical department which receive SLE patients, accountting to 92.3%.The SLE patients'average length of stay were decreasing, amouting by 34.0% from 2006 to 1997. The median of hospital day of SLE patients was 14 days, inter-quartile range was 9~22 days. Arthralgia,rash,fever were the first symptoms in SLE patients; lupus nephritis, hypertension, pulmonary infection were principal disease in SLE patients. The mortality of hospital patients was 1.7%, the age of dead patients was ranging from 16 to 72 years old and the average age was 38.38±15.99. The primary risk factors of SLE death were respiratory failure, NPSLE, cerbral infarction, cerebral hemorrhage, pericarditis, circulatory failure, liver function damage and onset acuted and critical.Conclusion There was an increasing trend of the hospitalized patients'number during the period from 1997 to 2006 and a descending tendency of the SLE hospitalized patients'average length stay. The treatment prescription for SLE was utility and the life expectancy was lengthening. The main risk factors of SLE death were respiratory failure, NPSLE, cerbral infarction, cerebral hemorrhage, pericarditis, circulatory failure, liver function damage and onset acuted and critica. It should be strengthen the clinical monitor and treatment directly. A study on the differences of clinical and laboratory presentations among systemic lupus erythematosus patients of different gender and ages and relations between themObjective To understand the differences of clinical and laboratory presentations among systemic lupus erythematosus(SLE) patients of different gender and ages, and relations between clinical and laboratory presentations, conduce to research disease deeply, discover potential damage and provide clues for pathogenesis research.Methods We used the retrospective study, analyzing the clinical and laboratory presentations of 2250 SLE patients on different gender and ages(children group<15, child-bearing period group is 15-49, senior group>49), and doing the relevance analysis for clinical and laboratory presentations by personχ2 test.Results The male patients exceeded female patients in suffering fever, while in suffering alopecie, female patients embodied predominally than that of male. The incidence of erythema was decreasing by the age of increase, while the incidence of pulmonary infection was increasing by the age increase. The child-bearing period group had the highest incidence of lupus nephritis and alopecie, the child-bearing period group's incidence of erythema and alopecie was higher than other groups in male patients. The female patients'rate of positive in anti-SSA antibody was higher than the male patients, the female patients'rate of positive in anti-SSA antibody was higher than male patients in senior group. The female patients'rate of positive in anti-dsDNA antibody,anti-uRNP antibody,anti-Sm antibody were decreasing by the age of increase, the child-bearing period group had the highest rate of positive in anti-SSA antibody, anti-SSB antibody, descending of complement C4. The male patients'rate of positive in anti-SSA antibody, anti-uRNP antibody was decreasing by the age of increase, the rate of positive in elevated CRP was increasing by the age increase, the child-bearing period group had the highest rate of positive in anti-Sm antibody, descended C3 and descended C4.The anti-dsDNA antibody(+) had the positive correlation with the lupus nephritis and pulmonary infection. The ANA(+) had the positive correlation with the arthritis, and the negative correlation with the lupus nephritis. The anti-uRNP antibody(+) had the positive correlation with the Raynaud phenomenon, arthritis, erythema and the negative correlation with the hypertension. The anti-Sm antibody(+) had the positive correlation with the arthritis and erythema. The APLA(+) had the positive correlation with the blood vessel embolism. The anti-SSA antibody(+) had the positive correlation with the dental ulcer. The anti-SSB antibody had no association with any clinical manifestation. The elevated CRP had the positive correlation with the hydrohymenitis, fever, hydrohymenitis and the negative correlation with the erythema. The descended C3 had the positive correlation with the lupus nephritis, hypertension and alopecie. The descended C4 had the positive correlation with the lupus nephritis. The descended PLT had the positive correlation with the central nerve damage and the negative correlation with the arthritis, erythema. The descended WBC had the positive correlation with the fever and the negative correlation with the lupus nephritis, hypertension.Conclusion 1) There were no distinctive differences on the clinical and laboratory presentations between the male and the female SLE patients. 2) Comparing with male patients, female patients had more differences in clinical presentations among different age group, such as female patients had the most positive rates of erythema in children group, child-bearing period patients had the most positive rates of lupus nephritis, senior group patients had the most positive rates of pulmonary infection. 3) There were many disparities in laboratory presentations among different age groups, there were six indexes have statistical significance among different age groups both male and female patients, such as female patients had the most positive rates of anti-dsDNA antibody in children group and the most positive rates of anti-SSA antibody in child-bearing period group, male patients had the most positive rates of anti-SSA antibody in children group, the most positive rates of anti-Sm antibody in child-bearing period group and the most positive rates of elevated CRP in senior group. 4)There were existed a invariable associations between clinical and laboratory presentations, such as the anti-dsDNA antibody and lupus nephritis, pulmonary infection, anti-phospholipid antibody and blood vessel embolism, descended PLT and central nerve damage, etc.
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