| Guillain-Barre syndrome, which used to be named acute inflammatory demyelinating polyneuropathy, its acute stage is about one to two weeks. Children who with GBS most have a better prognosis than that of adults. The cause of this disease is still unclear. Most scholars think the cause is including immunization, which consist of cell immune and body immune. At present the most important therapy of GBS is immunological regulation. Corticosteroids has been proved no excellence in treat GBS by most researchs. Larges randomness statistics discovered that plasmapheresis has good therapeutic efficacy. plasmapheresis has its restriction because it need special equipment and technique. Immunoglobulin are used more popular, as it is simple and has less chance of infection. Most scholars think that IVIG is more effective for those motor disorder than who have chydermoperiostosis acroparalysis. This resarch is to observe the effectiveness of intravenou- immunoglobulin (IVIG) therapy in children with Guillain-Barre syndrome (GBS).Objective: To observe the effectiveness of intrave -nouimmunoglobulin (IVIG) therapy in children with Guillain-Barre syndrome (GBS). Methods; Fifty-two children with GBS which were from the pediatric of the first hospital of JiLin university from 2004 to 2008 were randomly divided into two groups, one group treated with IVIG, the other treated just with supportive therapeusis and their curative effects compared respectively in two groups. The mean age in IVIG group is eight years old (which from three years old to fifteen years old), there are one of third of them have infected before this event; the average day from invasion to treat is 4.08±0.79 days. Twenty-two patients in IVIG group have motor disorder, three of them have cranial never disorder, one of them has involved in respiratory muscle, and one need mechanical ventilation. The mean age in control group is seven years old (which from two years old to thirteen years old), there are one of forth of them have infected before this event; the average day from invasion to treat is 5.96±1.32 days. Twenty-three patients in control group have motor disorder, two of them have cranial never disorder, none of them has involved in respiratory muscle. Results; Patients in IVIG group recovered more rapidly than those in supportive group. The time to improve one Hudges score in IVIG group is 12.96±4.96 days, and it in the supportive group is 19.12±8.28 days. The time form the beginning of the disease to the symptom improve in IVIG group is (8.66±3.65) days, and which in another group is (12.88±5.43) days. The time of acute stage in IVIG group is (5.62±3.50) days, the control group is (8.80±3.31) days. Twenty-first children can walk independently after three months in IVIG group. In control group the numble is nine. The Hughes evaluation is applicable for those who have lower limb debility, but not suitable for whose major symptom is weak of upper limb or ataxic, we find thar IVIG is more effective for those have motor disorder. Conclusion: IVIG can relieve the symptoms of the patiens who got Guillain-Barre syndrome, and shorten the period of treatment, and improve the prognosis. IVIG therapy is safe and efficacious to children with GBS. IVIG do better for those has motor disturbance, it cannt shorten the period of duration of ventilation and improve the sensory disability. IVIG should use in the acute stage, its best dose is undefinite, but it is essential that IVIG can treat long time.
|
PDF Full Text Request