Research Of The Potential Toxic Effects Of Peracetic Acid's Aerosol On Human Body

Objective To evaluate the potential negative effects on human body after peracetic acid was used to disinfect public areas. Methods 29 volunteers (male: 14; female: 15) were enrolled to take part in the experiment. The indoor public areas were disinfected according to the'disinfection routine of contaminated things of sorts'issued by the Bureau of Disease Control. Subjects drew 5ml 4 times (20ml in total) peripheral blood to determine their blood routine, liver function, kidney function, histamine, IgE, SOD and MDA in the serum; before the exposure to aerosol of peracetic acid for the first time, after the exposure once and twice for the second and third time and 1 week later without exposure to the air for the fourth time. And lymphocytes were collected to determine their DNA damage by means of comet essay. At the same time a questionnaire about the subjective feeling was required to be filled in after the third time and the fourth time of drawing blood. Results All the volunteers feel, to different extent, uncomfortable after being exposed to the disinfected air, most of them complained about the irritation to eyes, mouths, throat and stomachs; the WBC count has the inclination to ascend (P<0.05); the average of monocyte shows the trend to increase (P<0.001); which means the exposure has potential threat to get inflammation. After 1 week from the last exposure to the air, some of the determined indexes come to the level before exposure, except the monocyte. The SOD levels show an inclination to decrease after the exposure to the disinfected air (P<0.001); the MDA, however, has the exactly opposite trend (P<0.001). Like the MDA, such tendency also exists in DNA damage (P<0.01). After 1 week from the last exposure to the air, SOD has the tendency to return to the level before exposure. However, MDA level and DNA damage remain significantly different between the results achieved respectively at the first and fourth time. The liver function, kidney function and immune indexes in this experiment didn't show significant change. Conclusion If the indoor was disinfected according to that established guideline, the exposed subjects will feel irritation; the ascending of monocyte and WBC will occur; damage of lipid peroxidation and DNA will also occur.