Empirical Study In Dogs With Brain Explosive Injury

Objective: The aims of this study was to produce shock wave to simulate vulnerating condition in real warfare surrounding with neotype spot explosive origin, to establish the model with brain purely explosive injury in dogs and to investigate early physiology, pathology and imageology of brain explosive injury in dogs, and then to establish rationale groundwork for enhancing the capability in prevention and cure of brain explosive injury.Method: 21 live dog models with different traumatic-condition purely explosive brain injury were established by use of neotype spot explosive origin. According to different distance between head and explosive origin the dogs were divided into three groups. Time of breathing holding, range of change of heart rate and range of fluctuation of mean arterial blood pressure and CT scan were recorded. The data was collected and analyzed statistically. After tests the animal were sacrificed and the brain tissue were taken to observe the pathological changes.Results: After blast, breathing holding occurred to all model dogs and the nearer distance between explosive origin and dog head, the longer breathing holding kept. The duration of breathing holding was significantly different among different groups (P<0.05). The decrease of heart rate and blood pressure were observed, but the extent of decrease was not significant among different groups(P>0.05). According to the CT scan of brain, the nearer distance between explosive origin and dog head, the more the quantity of subdural hematoma (P<0.05). There were different extent of pathological changes including hematocele of frontal antrum contusion and laceration of brain, subdural hematoma, brain stem hemorrhage.Conclusion: After blast, the changes of vital sign (BR, HR and MABP) indirectly reflect the damage in nerve center. It's necessary to supply adjunctive therapy for respiration and circulation. The brain edema, contusion and laceration of brain and subdural hematoma are general,to which the early diagnose, treat and positively operational intervention may greatly improve prognosis.