The Distribution Of Pathogenic Fungi In Patients With Onychomycosis In West China Hospital And The Analysis Of Compliance To Oral Antifungal Drugs

Objectives: To investigate the distribution of pathogenic fungi in patientswith onychomycosis in West China Hospital. To analyze the compliance ofpatients with onychomycosis to oral antifungal drugs.Methods: To innoculate the nail scraps of each outpatient withonychomycosis in three media (SDA with or without cycloheximide, and therapeseed oil medium). The physiological and morphological methods wereapplied to identify the species of fungi. The treatment was decided bydermatologist, and the information of each patient was collected.Results: We collected 151 patients, and 147 pathomycetes were isolated bymultipoint cultivation. The dermatophyte was dominant species in allpathomycetes of onychomycosis (55.8%). The yeast was 27.9% (41/147) andthe mold was 16.3% (24/147). Candida albicans (3/41) was much fewer thannon-Candida albicans (38/41). Malassezia were isolated from 14 patients.Simplex infection of onychomyc0sis caused by dermatophyte was noted(67.0%), especially Trichophyton rubrum (62.6%). Trichophyton rubrum andyeast were dominant species in mixed infection (77.8%). Sex, infected position, and clinical type of onychomycosis were notrelated to pathogenic fungi.It was only 20% (28/140) that the compliance of patient withonychomycosis to oral antifungal drugs in West China Hospital. Twenty-twopatients were cured, occupied 78.6% (22/28) in those complied. The capitalcause of incompliance is too expensive of the drugs (72.3%).Conclusions: The dermatophyte was dominant species of onychomycosis,and the mold could not to be ignored. It was only 20% that the compliance ofpatient with onychomycosis to oral antifungal drugs in West China Hospital.